Neuro-Nano Interfaces: Utilizing Nano-Coatings and Nanoparticles to Enable Next-Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation

Ashlyn T. Young; Neil Cornwell; Michael A. Daniele

doi:10.1002/adfm.201700239

Neuro-Nano Interfaces: Utilizing Nano-Coatings and Nanoparticles to Enable Next-Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation

Advanced Functional Materials ◽

10.1002/adfm.201700239 ◽

2017 ◽

Vol 28 (12) ◽

pp. 1700239 ◽

Cited By ~ 11

Author(s):

Ashlyn T. Young ◽

Neil Cornwell ◽

Michael A. Daniele

Keyword(s):

Neural Stimulation ◽

Electrophysiological Recording ◽

Biochemical Modulation ◽

Next Generation

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Neuro Interfaces: Neuro-Nano Interfaces: Utilizing Nano-Coatings and Nanoparticles to Enable Next-Generation Electrophysiological Recording, Neural Stimulation, and Biochemical Modulation (Adv. Funct. Mater. 12/2018)

Advanced Functional Materials ◽

10.1002/adfm.201870079 ◽

2018 ◽

Vol 28 (12) ◽

pp. 1870079 ◽

Cited By ~ 2

Author(s):

Ashlyn T. Young ◽

Neil Cornwell ◽

Michael A. Daniele

Keyword(s):

Neural Stimulation ◽

Electrophysiological Recording ◽

Biochemical Modulation ◽

Next Generation

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Fate of sperm membrane in fertilized ova

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100146047 ◽

1993 ◽

Vol 51 ◽

pp. 40-41

Author(s):

Frank J. Longo

Keyword(s):

Electron Microscopy ◽

Electrical Activity ◽

Sea Urchins ◽

Morphological Changes ◽

Integrated System ◽

Electrophysiological Recording ◽

Experimental Conditions ◽

The Status ◽

Sperm Membrane ◽

Temporal And Spatial

Measurement of the egg's electrical activity, the fertilization potential or the activation current (in voltage clamped eggs), provides a means of detecting the earliest perceivable response of the egg to the fertilizing sperm. By using the electrical physiological record as a “real time” indicator of the instant of electrical continuity between the gametes, eggs can be inseminated with sperm at lower, more physiological densities, thereby assuring that only one sperm interacts with the egg. Integrating techniques of intracellular electrophysiological recording, video-imaging, and electron microscopy, we are able to identify the fertilizing sperm precisely and correlate the status of gamete organelles with the first indication (fertilization potential/activation current) of the egg's response to the attached sperm. Hence, this integrated system provides improved temporal and spatial resolution of morphological changes at the site of gamete interaction, under a variety of experimental conditions. Using these integrated techniques, we have investigated when sperm-egg plasma membrane fusion occurs in sea urchins with respect to the onset of the egg's change in electrical activity.

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