Organocatalytic Michael/Michael Cycloaddition Enabled Asymmetric Construction of Hexahydroxanthones with Skeletal Diversity

2019 ◽  
Vol 361 (12) ◽  
pp. 2836-2843 ◽  
Author(s):  
Xiong‐Li Liu ◽  
Qi‐Di Wei ◽  
Xiong Zuo ◽  
Sheng‐Wen Xu ◽  
Zhen Yao ◽  
...  
Keyword(s):  
Skeletal Diversity

Achieving Skeletal Diversity in Peptide Macrocycles through The Use of Heterocyclic Grafts

2018 ◽  
Vol 24 (28) ◽  
pp. 7074-7082 ◽  
Author(s):  
Sherif J. Kaldas ◽  
Andrei K. Yudin
Keyword(s):  
Skeletal Diversity

scholarly journals Divergent synthesis of complex diterpenes through a hybrid oxidative approach

Science ◽  
2020 ◽  
Vol 369 (6505) ◽  
pp. 799-806 ◽  
Author(s):  
Xiao Zhang ◽  
Emma King-Smith ◽  
Liao-Bin Dong ◽  
Li-Cheng Yang ◽  
Jeffrey D. Rudolf ◽  
...  
Keyword(s):  
Natural Products ◽  
De Novo ◽  
Biological Activities ◽  
Structural Complexity ◽  
Enzymatic Oxidation ◽  
Chemical Tools ◽  
Skeletal Rearrangements ◽  
Skeletal Diversity

Polycyclic diterpenes exhibit many important biological activities, but de novo synthetic access to these molecules is highly challenging because of their structural complexity. Semisynthetic access has also been limited by the lack of chemical tools for scaffold modifications. We report a chemoenzymatic platform to access highly oxidized diterpenes by a hybrid oxidative approach that strategically combines chemical and enzymatic oxidation methods. This approach allows for selective oxidations of previously inaccessible sites on the parent carbocycles and enables abiotic skeletal rearrangements to additional underlying architectures. We synthesized a total of nine complex natural products with rich oxygenation patterns and skeletal diversity in 10 steps or less from ent-steviol.

scholarly journals Exploring Skeletal Diversity via Ring Contraction of Glycal-Derived Scaffolds.

ChemInform ◽  
2007 ◽  
Vol 38 (9) ◽  
Author(s):  
Adam R. Yeager ◽  
Geanna K. Min ◽  
John A. Jr. Porco ◽  
Scott E. Schaus
Keyword(s):  
Ring Contraction ◽  
Skeletal Diversity

ChemInform Abstract: Powerful Approach to Heterocyclic Skeletal Diversity by Sequential Three-Component Reaction of Amines, Isothiocyanates, and 1,2-Diaza-1,3-dienes.

ChemInform ◽  
2012 ◽  
Vol 43 (21) ◽  
pp. no-no
Author(s):  
Orazio A. Attanasi ◽  
Silvia Bartoccini ◽  
Gianfranco Favi ◽  
Gianluca Giorgi ◽  
Francesca Romana Perrulli ◽  
...  
Keyword(s):  
Three Component Reaction ◽  
Powerful Approach ◽  
Skeletal Diversity

An Oligomer-Based Approach to Skeletal Diversity in Small-Molecule Synthesis

2006 ◽  
Vol 128 (46) ◽  
pp. 14766-14767 ◽  
Author(s):  
David A. Spiegel ◽  
Frank C. Schroeder ◽  
Jeremy R. Duvall ◽  
Stuart L. Schreiber
Keyword(s):  
Small Molecule ◽  
Small Molecule Synthesis ◽  
Skeletal Diversity

scholarly journals Combinatorial Libraries of Bis-heterocyclic Compounds with Skeletal Diversity

2008 ◽  
Vol 10 (6) ◽  
pp. 923-933 ◽  
Author(s):  
Miroslav Soural ◽  
Isabelle Bouillon ◽  
Viktor Krchňák
Keyword(s):  
Heterocyclic Compounds ◽  
Combinatorial Libraries ◽  
Skeletal Diversity

Skeletal diversity by allylation/RCM on Ugi four-component coupling reaction products

2006 ◽  
Vol 47 (27) ◽  
pp. 4763-4767 ◽  
Author(s):  
Masato Oikawa ◽  
Shinya Naito ◽  
Makoto Sasaki
Keyword(s):  
Coupling Reaction ◽  
Reaction Products ◽  
Skeletal Diversity
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