Clinical presentation and natural history of patients with essential thrombocythemia and the Philadelphia chromosome

1988 ◽  
Vol 27 (2) ◽  
pp. 77-83 ◽  
Author(s):  
D. B. Stoll ◽  
P. Peterson ◽  
R. Exten ◽  
J. Laszlo ◽  
A. V. Pisciotta ◽  
...  
Keyword(s):  
Natural History ◽  
Essential Thrombocythemia ◽  
Clinical Presentation ◽  
Philadelphia Chromosome ◽  
History Of

scholarly journals BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients: Clinical Presentation

Blood ◽  
1997 ◽  
Vol 90 (7) ◽  
pp. 2768-2771 ◽  
Author(s):  
Dorit Blickstein ◽  
Adina Aviram ◽  
Jacob Luboshitz ◽  
Miron Prokocimer ◽  
Pinhas Stark ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Essential Thrombocythemia ◽  
Clinical Presentation ◽  
Molecular Level ◽  
Philadelphia Chromosome ◽  
Nested Polymerase Chain Reaction ◽  
History Of ◽  
Polymerase Chain ◽  
Positive Groups

Abstract One of the diagnostic criteria of essential thrombocythemia (ET) is the absence of the Philadelphia chromosome (Ph-neg). On the molecular level, Ph-neg ET patients may carry BCR-ABL transcript. The natural history of BCR-ABL positive Ph-neg ET patients is undetermined. We examined the BCR-ABL status by reverse transcriptase two-step nested polymerase chain reaction in bone marrow aspirates of 25 Ph-neg ET patients. We found 12 BCR-ABL positive and 13 BCR-ABL negative patients in the study group. The comparison showed that the two groups had similar clinical and laboratory characteristics, except for a significant increased patients' age and decreased polymorphonuclear cell count in the BCR-ABL positive group. During a median follow-up of 20 and 22.5 months for the BCR-ABL negative and positive groups, respectively, there was neither blastic transformation nor unrelated death in both groups. We conclude that it is important to look for BCR-ABL transcript in Ph-neg ET patients and to follow them closely to investigate the nature of this translocation in this group of patients.

scholarly journals BCR-ABL Transcripts in Bone Marrow Aspirates of Philadelphia-Negative Essential Thrombocythemia Patients: Clinical Presentation

Blood ◽  
1997 ◽  
Vol 90 (7) ◽  
pp. 2768-2771 ◽  
Author(s):  
Dorit Blickstein ◽  
Adina Aviram ◽  
Jacob Luboshitz ◽  
Miron Prokocimer ◽  
Pinhas Stark ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Essential Thrombocythemia ◽  
Clinical Presentation ◽  
Molecular Level ◽  
Philadelphia Chromosome ◽  
Nested Polymerase Chain Reaction ◽  
History Of ◽  
Polymerase Chain ◽  
Positive Groups

One of the diagnostic criteria of essential thrombocythemia (ET) is the absence of the Philadelphia chromosome (Ph-neg). On the molecular level, Ph-neg ET patients may carry BCR-ABL transcript. The natural history of BCR-ABL positive Ph-neg ET patients is undetermined. We examined the BCR-ABL status by reverse transcriptase two-step nested polymerase chain reaction in bone marrow aspirates of 25 Ph-neg ET patients. We found 12 BCR-ABL positive and 13 BCR-ABL negative patients in the study group. The comparison showed that the two groups had similar clinical and laboratory characteristics, except for a significant increased patients' age and decreased polymorphonuclear cell count in the BCR-ABL positive group. During a median follow-up of 20 and 22.5 months for the BCR-ABL negative and positive groups, respectively, there was neither blastic transformation nor unrelated death in both groups. We conclude that it is important to look for BCR-ABL transcript in Ph-neg ET patients and to follow them closely to investigate the nature of this translocation in this group of patients.

Clinical Presentation and Natural History of Mesothelioma: Abdominal

2006 ◽  
pp. 391-401 ◽  
Author(s):  
Claire F. Verschraegen ◽  
Charles R. Key ◽  
Raffit Hassan
Keyword(s):  
Natural History ◽  
Clinical Presentation ◽  
History Of

scholarly journals Spontaneous thrombosis of internal carotid artery: a natural history of giant carotid cavernous aneurysms

2009 ◽  
Vol 67 (2a) ◽  
pp. 278-283 ◽  
Author(s):  
Lucas Perez de Vasconcellos ◽  
Juan Antônio Castro Flores ◽  
Mário Luiz Marques Conti ◽  
José Carlos Esteves Veiga ◽  
Carmen Lúcia Penteado Lancellotti
Keyword(s):  
Carotid Artery ◽  
Natural History ◽  
Internal Carotid Artery ◽  
Collateral Circulation ◽  
Internal Carotid ◽  
Clinical Presentation ◽  
Spontaneous Thrombosis ◽  
Related Factors ◽  
Trigeminal Neuropathy ◽  
History Of

OBJECTIVE: To describe five cases of giant carotid cavernous aneurysms which evolved with spontaneous thrombosis of internal carotid artery (STICA), with emphasis at epidemiology, clinical presentation, natural history, related factors and neurological outcome. METHOD: There were 711 consecutives patients with 802 aneurysms with and without surgical treatment during a period of 19 years. We selected 35 patients with 40 carotid cavernous aneurysms (5%) of which 20 (50%) were giant aneurysms. Among those cases, 5 patients evolved with STICA (25%). Symptoms and findings at presentation were recorded and compared with those at outcome. RESULTS: Clinical presentation was commonly related to atherosclerotic factors such as elevated blood pressure (80%), diabetes mellitus (40%) and dislipidemy (40%). All patients presented with hemicranial headache, ophthalmparesy and retro bulbar pain, and after STICA all presented improvement of symptoms. After STICA, 4 patients had regression of deficit, 2 partial and 2 complete. Four patients had sensorial trigeminal neuropathy in V1 and V2 territories, also showing improvement of symptoms after STICA. CONCLUSION: STICA is a common outcome in giant carotid cavernous aneurysms, and is related with significant improvement of symptoms; however, it may be catastrophic for those patients without efficient collateral circulation.

Natural history of polycythemia vera and essential thrombocythemia presenting with splanchnic vein thrombosis

2020 ◽  
Vol 99 (4) ◽  
pp. 791-798 ◽  
Author(s):  
Alberto Alvarez-Larrán ◽  
◽  
Arturo Pereira ◽  
Marta Magaz ◽  
Juan Carlos Hernández-Boluda ◽  
...  
Keyword(s):  
Natural History ◽  
Polycythemia Vera ◽  
Essential Thrombocythemia ◽  
Splanchnic Vein Thrombosis ◽  
Vein Thrombosis ◽  
History Of

scholarly journals Clinical presentation and natural history of autoimmune hepatitis

2014 ◽  
Vol 3 (1) ◽  
pp. 9-11 ◽  
Author(s):  
Michael R. Lucey ◽  
John M. Vierling
Keyword(s):  
Natural History ◽  
Autoimmune Hepatitis ◽  
Clinical Presentation ◽  
History Of

scholarly journals The Philadelphia chromosome in human macrophages

Blood ◽  
1977 ◽  
Vol 49 (3) ◽  
pp. 367-370 ◽  
Author(s):  
DW Golde ◽  
C Burgaleta ◽  
RS Sparkes ◽  
MJ Cline
Keyword(s):  
Bone Marrow ◽  
Natural History ◽  
Cell Line ◽  
Bone Marrow Cells ◽  
Philadelphia Chromosome ◽  
Mononuclear Phagocyte ◽  
Chronic Myelocytic Leukemia ◽  
Human Macrophages ◽  
Myelocytic Leukemia ◽  
History Of

Three patients with chronic myelocytic leukemia in different phases of the natural history of the disease were studied. Their bone marrow cells were cultured under conditions favoring macrophage proliferation, and parallel cytogenetic and cytochemical studies were performed. All cell metaphases examined contained the Ph1 chromosome at a time when more than 80% of these metaphases were in identifiable macrophages. We conclude that the mononuclear phagocyte cell line contains the abnormal chromosome in Ph1-positive chronic myelocytic leukemia.

OC3.04.1 CLINICAL PRESENTATION AND NATURAL HISTORY OF PORTAL CAVERNOMA (PC) IN 60 PATIENTS WITH AND WITHOUT LIVER CIRRHOSIS

2008 ◽  
Vol 40 ◽  
pp. S45
Author(s):  
A. De Santis ◽  
F. Gigliotti ◽  
F. Cristofari ◽  
S. Trapani ◽  
F. Giubilo ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Natural History ◽  
Clinical Presentation ◽  
Portal Cavernoma ◽  
History Of
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