Folic acid treatment of fragile X males: A further study

Herein, we synthesized N- and P-doped carbons (PN-doped carbons) by controlled phosphoric acid treatment (CPAT) of folic acid (FA) and probed their ability to catalyze the oxygen reduction reaction at the cathode of a fuel cell. Precursors obtained by heating FA in the presence of phosphoric acid at temperatures of 400–1000 °C were further annealed at 1000 °C to afford PN-doped carbons. The extent of precursor P-doping was maximized at 700 °C, and the use of higher temperatures resulted in activation and increased porosity rather than in increased P content. The P/C atomic ratios of PN-doped carbons were well correlated with those of precursors, which indicated that CPAT was well suited for the preparation of PN-doped carbons. Carbon prepared using a CPAT temperature of 700 °C exhibited the highest oxygen reduction reaction (ORR) activity and was shown to contain –C–PO2 and –C–PO3 moieties as the major P species and pyridinic N as the major N species; moreover, no N–P bonds were detected. The presence of –C–PO2 and –C–PO3 units was concluded to decrease the work function and thus raise the Fermi level above the standard O2/H2O reduction potential, which resulted in enhanced ORR activity. Finally, CPAT was concluded to be applicable to the synthesis of PN-doped carbons from N-containing organic compounds other than FA.

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Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene

Nature Genetics ◽

10.1038/ng0796-275 ◽

1996 ◽

Vol 13 (3) ◽

pp. 275-283 ◽

Cited By ~ 172

Author(s):

Qi Zhao ◽

Richard R. Behringer ◽

Benoit de Crombrugghe

Keyword(s):

Folic Acid ◽

Acid Treatment ◽

Homeobox Gene

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“New” cardiovascular risk factors in patients with chronic kidney disease: Role of folic acid treatment

Kidney International ◽

10.1111/j.1523-1755.2005.09309.x ◽

2005 ◽

Vol 67 ◽

pp. S39-S43 ◽

Cited By ~ 13

Author(s):

Beatriz Bayés ◽

Mari Cruz Pastor ◽

Jordi Bonal ◽

Ramón Romero

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Folic Acid ◽

Cardiovascular Risk ◽

Kidney Disease ◽

Cardiovascular Risk Factors ◽

Acid Treatment

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Folic acid for fragile X syndrome

Cochrane Database of Systematic Reviews ◽

10.1002/14651858.cd008476.pub2 ◽

2011 ◽

Cited By ~ 6

Author(s):

José-Ramón Rueda ◽

Javier Ballesteros ◽

Virginia Guillen ◽

Maria-Isabel Tejada ◽

Ivan Solà

Keyword(s):

Folic Acid ◽

Fragile X Syndrome ◽

Fragile X

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Synthesis of P- and N-doped carbon catalysts for the oxygen reduction reaction via controlled phosphoric acid treatment of folic acid

Beilstein Journal of Nanotechnology ◽

10.3762/bjnano.10.148 ◽

2019 ◽

Vol 10 ◽

pp. 1497-1510 ◽

Cited By ~ 1

Author(s):

Rieko Kobayashi ◽

Takafumi Ishii ◽

Yasuo Imashiro ◽

Jun-ichi Ozaki

Keyword(s):

Folic Acid ◽

Phosphoric Acid ◽

Oxygen Reduction Reaction ◽

Oxygen Reduction ◽

Acid Treatment ◽

Carbon Materials ◽

Reduction Reaction ◽

P Content ◽

Orr Activity ◽

Carbon Catalysts

Herein, we synthesized P- and N-doped carbon materials (PN-doped carbon materials) through controlled phosphoric acid treatment (CPAT) of folic acid (FA) and probed their ability to catalyze the oxygen reduction reaction (ORR) at the cathode of a fuel cell. Precursors obtained by heating FA in the presence of phosphoric acid at temperatures of 400–1000 °C were further annealed at 1000 °C to afford PN-doped carbon materials. The extent of precursor P doping was maximized at 700 °C, and the use of higher temperatures resulted in activation and increased porosity rather than in increased P content. The P/C atomic ratios of PN-doped carbon materials correlated well with those of the precursors, which indicated that CPAT is well suited for the preparation of PN-doped carbon materials. The carbon material prepared using a CPAT temperature of 700 °C exhibited the highest ORR activity and was shown to contain –C–PO2 and –C–PO3 moieties as the major P species and pyridinic N as the major N species. Moreover, no N–P bonds were detected. It was concluded that the presence of –C–PO2 and –C–PO3 units decreases the work function and thus raises the Fermi level above the standard O2/H2O reduction potential, which resulted in enhanced ORR activity. Finally, CPAT was concluded to be applicable to the synthesis of PN-doped carbon materials from N-containing organic compounds other than FA.

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