Genetic association between NRG1 and schizophrenia, major depressive disorder, bipolar disorder in Han Chinese population

2016 ◽  
Vol 171 (3) ◽  
pp. 468-478 ◽  
Author(s):  
Zujia Wen ◽  
Jianhua Chen ◽  
Raja Amjad Waheed Khan ◽  
Zhijian Song ◽  
Meng Wang ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Genetic Association ◽  
Chinese Population ◽  
Han Chinese ◽  
Major Depressive ◽  
Han Chinese Population

scholarly journals CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population

2014 ◽  
Vol 204 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Kuanjun He ◽  
Zhiguo An ◽  
Qingzhong Wang ◽  
Tao Li ◽  
Zhiqiang Li ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Chinese Population ◽  
Susceptibility Gene ◽  
Han Chinese ◽  
Major Depressive ◽  
Han Chinese Population ◽  
Risk Gene ◽  
Voltage Dependent ◽  
Shared Risk

BackgroundCommon psychiatric disorders are highly heritable, indicating that genetic factors play an important role in their aetiology. The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder.AimsTo investigate whether CACNA1C is a susceptibility gene for schizophrenia and major depressive disorder in the Han Chinese population.MethodWe carried out a case–control study of 1235 patients with schizophrenia, 1045 with major depressive disorder and 1235 healthy controls. A tag single nucleotide polymorphism (SNP) rs1006737 along with another 10 tag SNPs in the CACNA1C gene were genotyped in all samples.ResultsWe found that rs1006737 was associated with both schizophrenia (Pallele = 0.0014, Pgenotype = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134–1.690) and major depressive disorder (Pallele = 0.0007, Pgenotype = 0.003, OR = 1.425, 95% CI 1.160–1.752).ConclusionsOur findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.

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