Venlafaxine vs. paroxetine in the acute phase of treatment for major depressive disorder among Han Chinese population in Taiwan

2007 ◽  
Vol 32 (4) ◽  
pp. 353-363 ◽  
Author(s):  
Y.-S. Wu ◽  
Y.-C. Chen ◽  
R.-B. Lu
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Acute Phase ◽  
Chinese Population ◽  
Han Chinese ◽  
Major Depressive ◽  
Han Chinese Population

scholarly journals CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population

2014 ◽  
Vol 204 (1) ◽  
pp. 36-39 ◽  
Author(s):  
Kuanjun He ◽  
Zhiguo An ◽  
Qingzhong Wang ◽  
Tao Li ◽  
Zhiqiang Li ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Chinese Population ◽  
Susceptibility Gene ◽  
Han Chinese ◽  
Major Depressive ◽  
Han Chinese Population ◽  
Risk Gene ◽  
Voltage Dependent ◽  
Shared Risk

BackgroundCommon psychiatric disorders are highly heritable, indicating that genetic factors play an important role in their aetiology. The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder.AimsTo investigate whether CACNA1C is a susceptibility gene for schizophrenia and major depressive disorder in the Han Chinese population.MethodWe carried out a case–control study of 1235 patients with schizophrenia, 1045 with major depressive disorder and 1235 healthy controls. A tag single nucleotide polymorphism (SNP) rs1006737 along with another 10 tag SNPs in the CACNA1C gene were genotyped in all samples.ResultsWe found that rs1006737 was associated with both schizophrenia (Pallele = 0.0014, Pgenotype = 0.006, odds ratio (OR) = 1.384, 95% CI 1.134–1.690) and major depressive disorder (Pallele = 0.0007, Pgenotype = 0.003, OR = 1.425, 95% CI 1.160–1.752).ConclusionsOur findings support CACNA1C being a risk gene for both schizophrenia and major depressive disorder in the Han Chinese population.

scholarly journals Role played by the SP4 gene in schizophrenia and major depressive disorder in the Han Chinese population

2016 ◽  
Vol 208 (5) ◽  
pp. 441-445 ◽  
Author(s):  
Jianhua Chen ◽  
Kuanjun He ◽  
Qingzhong Wang ◽  
Zhiqiang Li ◽  
Jiawei Shen ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Chinese Population ◽  
Han Chinese ◽  
Nucleotide Polymorphisms ◽  
Bonferroni Correction ◽  
Case Control Studies ◽  
Major Depressive ◽  
Han Chinese Population ◽  
Common Risk Factors

BackgroundPsychiatric disorders such as schizophrenia and major depressive disorder (MDD) are likely to be caused by multiple susceptibility genes, each with small effects in increasing the risk of illness. Identifying DNA variants associated with schizophrenia and MDD is a crucial step in understanding the pathophysiology of these disorders.AimsTo investigate whether the SP4 gene plays a significant role in schizophrenia or MDD in the Han Chinese population.MethodWe focused on nine single nucleotide polymorphisms (SNPs) harbouring the SP4 gene and carried out case–control studies in 1235 patients with schizophrenia, 1045 patients with MDD and 1235 healthy controls recruited from the Han Chinese population.ResultsWe found that rs40245 was significantly associated with schizophrenia in both allele and genotype distributions (Pallele = 0.0005, Pallele = 0.004 after Bonferroni correction; Pgenotype = 0.0023, Pgenotype = 0.0184 after Bonferroni correction). The rs6461563 SNP was significantly associated with schizophrenia in the allele distributions (Pallele = 0.0033, Pallele = 0.0264 after Bonferroni correction).ConclusionsOur results suggest that common risk factors in the SP4 gene are associated with schizophrenia, although not with MDD, in the Han Chinese population.

SNAP25 Is Associated With Schizophrenia and Major Depressive Disorder in the Han Chinese Population

2015 ◽  
Vol 76 (01) ◽  
pp. e76-e82 ◽  
Author(s):  
Qingzhong Wang ◽  
Yanlin Wang ◽  
Weidong Ji ◽  
Guoquan Zhou ◽  
Kuanjun He ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Chinese Population ◽  
Han Chinese ◽  
Major Depressive ◽  
Han Chinese Population

The GSK3B gene confers risk for both major depressive disorder and schizophrenia in the Han Chinese population

2015 ◽  
Vol 185 ◽  
pp. 149-155 ◽  
Author(s):  
Jianhua Chen ◽  
Meng Wang ◽  
Raja Amjad Waheed Khan ◽  
Kuanjun He ◽  
Qingzhong Wang ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Chinese Population ◽  
Han Chinese ◽  
Major Depressive ◽  
Han Chinese Population
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