scholarly journals Pathogenic protein seeding in alzheimer disease and other neurodegenerative disorders

2011 ◽  
Vol 70 (4) ◽  
pp. 532-540 ◽  
Author(s):  
Mathias Jucker ◽  
Lary C. Walker
Keyword(s):  
Alzheimer Disease ◽  
Neurodegenerative Disorders

scholarly journals Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders

2020 ◽  
Vol 77 (8) ◽  
pp. 955 ◽  
Author(s):  
Antoine Leuzy ◽  
Ruben Smith ◽  
Rik Ossenkoppele ◽  
Alexander Santillo ◽  
Edilio Borroni ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Alzheimer Disease ◽  
Neurodegenerative Disorders ◽  
Diagnostic Performance ◽  
Emission Tomography ◽  
Positron Emission

scholarly journals Anapsos: Neuroimmunotrophic Treatment in Alzheimer Disease and Neurodegenerative Disorders

1997 ◽  
Vol 3 (2) ◽  
pp. 181-206 ◽  
Author(s):  
Antön Alvarez ◽  
José J. Miguel-Hidalgo ◽  
Lucía Fernandez-Novoa ◽  
Joaquín Díaz ◽  
José M. Sempere ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Neurodegenerative Disorders

scholarly journals Dietary Factors and Neurodegenerative Disorders: An Umbrella Review of Meta-Analyses of Prospective Studies

2020 ◽  
Vol 11 (5) ◽  
pp. 1161-1173
Author(s):  
Janett Barbaresko ◽  
Arno Werner Lellmann ◽  
Annemarie Schmidt ◽  
Andreas Lehmann ◽  
Anna Maria Amini ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Parkinson Disease ◽  
Prospective Studies ◽  
Neurodegenerative Disorders ◽  
Risk Of Bias ◽  
Dietary Factors ◽  
Umbrella Review ◽  
Quality Of Evidence ◽  
Meta Analyses

ABSTRACT Diet has been hypothesized to be associated with neurodegenerative disorders. The aim was to conduct an umbrella review to summarize and evaluate the current evidence of prospective associations between any dietary factors and the incidence of neurodegenerative disorders. We conducted a systematic search in PubMed, Embase, and the Cochrane library up to November 2019 to identify systematic reviews with meta-analyses of prospective studies investigating the association between dietary factors (dietary patterns, foods and beverages, nutrients, and phytochemicals) and neurodegenerative disorders (cognitive decline, cognitive impairment, Alzheimer disease, all-cause dementia, and Parkinson disease). Summary risk ratios (SRRs) and 95% CIs were recalculated using a random effects model. We evaluated the risk of bias of identified meta-analyses and the quality of evidence for all associations. In total, 20 meta-analyses including 98 SRRs were identified. All original meta-analyses were rated as being at high risk of bias. Methodological concerns related mainly to the inappropriate synthesis, assessment, and discussion of the risk of bias of primary studies. For the recalculated meta-analyses, quality of evidence was moderate for inverse associations between higher adherence to the Mediterranean diet (SRR: 0.63; 95% CI: 0.48, 0.82; n = 4 primary studies) and higher fish intake (SRR: 0.72; 95% CI: 0.59, 0.89; n = 6) and Alzheimer disease, as well as for tea consumption and all-cause dementia (SRR: 0.74; 95% CI: 0.63, 0.88; n = 2) and Parkinson disease (SRR per 2 cups/d: 0.69; 95% CI: 0.54, 0.87; n = 5). This umbrella review provides a comprehensive overview of the available evidence on dietary factors and neurodegenerative disorders. The results indicate that the Mediterranean diet, fish, and tea could be inversely associated with neurodegenerative disorders. However, the quality of evidence was generally low, suggesting that further studies are likely to change the overall estimates. Thus, more well-conducted research, also investigating other dietary factors in association with neurodegenerative disorders, is warranted.

scholarly journals Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

JAMA ◽  
2020 ◽  
Vol 324 (8) ◽  
pp. 772 ◽  
Author(s):  
Sebastian Palmqvist ◽  
Shorena Janelidze ◽  
Yakeel T. Quiroz ◽  
Henrik Zetterberg ◽  
Francisco Lopera ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Neurodegenerative Disorders

Marital idealization as an enduring buffer to distress among spouses of persons with Alzheimer disease

2010 ◽  
Vol 28 (1) ◽  
pp. 117-133 ◽  
Author(s):  
Norm O'Rourke ◽  
Amy Claxton ◽  
Anthony L. Kupferschmidt ◽  
JuliAnna Z. Smith ◽  
B. Lynn Beattie
Keyword(s):  
Alzheimer Disease ◽  
Caregiver Burden ◽  
Neurodegenerative Disorders ◽  
Family Caregiving ◽  
Multilevel Models ◽  
Well Being ◽  
Marital Relationships ◽  
Demographic Trends ◽  
Cross Sectional ◽  
One Year

Few disease processes affect the dynamics of marital relationships like neurodegenerative disorders. Illnesses such as Alzheimer disease strip older adults of a lifetime of memories and, in the latter stages, even the ability to recognize one’s spouse and children. In cross-sectional research, marital idealization (or the propensity to idealize one’s spouse and relationship) has emerged as significantly associated with the absence of distress among those caring for a spouse with Alzheimer disease. To extend prior findings, multilevel models were computed for the current study to demonstrate that marital idealization predicts both life satisfaction and the relative absence of caregiver burden one year later; moreover, change in marital idealization reflects a corresponding change in the psychological well-being of spouses over this same period ( N = 90). Results of this study are discussed relative to the distinct demands of caring for a spouse with a dementing disorder, the health benefits of positive illusions, and demographic trends suggesting that family caregiving will become increasingly prevalent in coming years.

scholarly journals Discriminative Accuracy of [18F]flortaucipir Positron Emission Tomography for Alzheimer Disease vs Other Neurodegenerative Disorders

JAMA ◽  
2018 ◽  
Vol 320 (11) ◽  
pp. 1151 ◽  
Author(s):  
Rik Ossenkoppele ◽  
Gil D. Rabinovici ◽  
Ruben Smith ◽  
Hanna Cho ◽  
Michael Schöll ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Alzheimer Disease ◽  
Neurodegenerative Disorders ◽  
Emission Tomography ◽  
Positron Emission
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