scholarly journals Intraspinal neural stem cell transplantation in amyotrophic lateral sclerosis: Phase 1 trial outcomes

2014 ◽  
Vol 75 (3) ◽  
pp. 363-373 ◽  
Author(s):  
Eva L. Feldman ◽  
Nicholas M. Boulis ◽  
Junguk Hur ◽  
Karl Johe ◽  
Seward B. Rutkove ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
Phase 1 ◽  
Phase 1 Trial ◽  
Trial Outcomes ◽  
Lateral Sclerosis

scholarly journals Intraspinal Stem Cell Transplantation in Amyotrophic Lateral Sclerosis

Neurosurgery ◽  
2013 ◽  
Vol 74 (1) ◽  
pp. 77-87 ◽  
Author(s):  
Jonathan Riley ◽  
Jonathan Glass ◽  
Eva L. Feldman ◽  
Meraida Polak ◽  
Jane Bordeau ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Neural Stem Cell ◽  
Ventral Horn ◽  
Perioperative Morbidity ◽  
Group D ◽  
Lateral Sclerosis

Abstract BACKGROUND: The first US Food and Drug Administration approved clinical trial for a stem cell-based treatment of amyotrophic lateral sclerosis has now been completed. OBJECTIVE: Primary aims assessed the safety of a direct microinjection-based technique and the toxicity of neural stem cell transplantation to the ventral horn of the cervical and thoracolumbar spinal cord. Results from thoracolumbar-only microinjection groups have been previously published. Cervical and cervical plus thoracolumbar microinjection group perioperative morbidity results are presented. METHODS: Eighteen microinjection procedures (n = 12 thoracolumbar [T10/11], n = 6 cervical [C3-5]) delivered NSI-566RSC (Neuralstem, Inc), a human neural stem cell, to 15 patients in 5 cohorts. Each injection series comprised 5 injections of 10 μL at 4-mm intervals. The patients in group A (n = 6) were nonambulatory and received unilateral (n = 3) or bilateral (n = 3) thoracolumbar microinjections. The patients in groups B to E were ambulatory and received either unilateral (group B, n = 3) or bilateral (group C, n = 3) thoracolumbar microinjection. Group D and E patients received unilateral cervical (group D, n = 3) or cervical plus bilateral thoracolumbar microinjection (group E, n = 3). RESULTS: Unilateral cervical (group D, n = 3) and cervical plus thoracolumbar (group E, n = 3) microinjections to the ventral horn have been completed in ambulatory patients. One patient developed a postoperative kyphotic deformity prompting completion of a laminoplasty in subsequent patients. Another required reoperation for wound dehiscence and infection. The solitary patient with bulbar amyotrophic lateral sclerosis required perioperative reintubation. CONCLUSION: Delivery of a cellular payload to the cervical or thoracolumbar spinal cord was well tolerated by the spinal cord in this vulnerable population. This encouraging finding supports consideration of this delivery approach for neurodegenerative, oncologic, and traumatic spinal cord afflictions.

Stem-cell transplantation into the frontal motor cortex in amyotrophic lateral sclerosis patients

Cytotherapy ◽  
2009 ◽  
Vol 11 (1) ◽  
pp. 26-34 ◽  
Author(s):  
Hector R. Martinez ◽  
Maria T. Gonzalez-Garza ◽  
Jorge E. Moreno-Cuevas ◽  
Enrique Caro ◽  
Eugenio Gutierrez-Jimenez ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Motor Cortex ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Lateral Sclerosis

Long-term survival in amyotrophic lateral sclerosis after stem cell transplantation into the frontal motor cortex

Cytotherapy ◽  
2016 ◽  
Vol 18 (6) ◽  
pp. 806-808 ◽  
Author(s):  
Héctor R. Martínez ◽  
María Teresa González-Garza ◽  
Jorge Moreno-Cuevas ◽  
César E. Escamilla-Ocañas ◽  
Juan Miguel Tenorio-Pedraza ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Motor Cortex ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Term Survival ◽  
Long Term Survival ◽  
Lateral Sclerosis

806 Intraspinal and Systemic Stem Cell Transplantation Delays Onset, Improves Survival in Transgenic Amyotrophic Lateral Sclerosis Mice

Neurosurgery ◽  
2001 ◽  
Vol 49 (2) ◽  
pp. 538-538
Author(s):  
Steven N. Kalkanis ◽  
Joy Dreibelbis ◽  
Christopher Welty ◽  
Jasmine Haque ◽  
Wilder Doucette ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Lateral Sclerosis

Stem cell transplantation for amyotrophic lateral sclerosis

2018 ◽  
Vol 31 (5) ◽  
pp. 655-661 ◽  
Author(s):  
Robert H. Baloh ◽  
Jonathan D. Glass ◽  
Clive N. Svendsen
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis in pregnancy: clinical outcome during the post-partum period after stem cell transplantation into the frontal motor cortex

Cytotherapy ◽  
2014 ◽  
Vol 16 (3) ◽  
pp. 402-405 ◽  
Author(s):  
Hector R. Martínez ◽  
Sergio Salazar Marioni ◽  
César E. Escamilla Ocañas ◽  
María Teresa Gonzalez Garza ◽  
Jorge E. Moreno-Cuevas
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Motor Cortex ◽  
Clinical Outcome ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Post Partum ◽  
Post Partum Period ◽  
Lateral Sclerosis ◽  
In Pregnancy

Stem Cell Transplantation in Amyotrophic Lateral Sclerosis Patients: Methodological Approach, Safety, and Feasibility

2012 ◽  
Vol 21 (9) ◽  
pp. 1899-1907 ◽  
Author(s):  
Héctor R. Martínez ◽  
Juan Francisco Molina-Lopez ◽  
María Teresa González-Garza ◽  
Jorge E. Moreno-Cuevas ◽  
Enrique Caro-Osorio ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Methodological Approach ◽  
Lateral Sclerosis
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