In recent years, there have been major advances in the management of many haematological conditions. As a result, there have been real improvements in long-term survival and workability, particularly among patients with haemoglobinopathies and haematological malignancies. Work is often not possible for many months during major treatments such as chemotherapy or haematological stem cell transplantation. However, more of these patients will return to the employment market after treatment than previously. With the exception of a few jobs that are contraindicated (including some in heavy or dangerous industries and commercial aviation), adjustments to work will enable most patients with haematological disorders to work efficiently and safely. Generic issues that should be considered for work adjustments include fatigue, impaired immunity, and bleeding tendency.