Enantioselective Synthesis of Chiral Oxime Ethers: Desymmetrization and Dynamic Kinetic Resolution of Substituted Cyclohexanones

2017 ◽  
Vol 129 (9) ◽  
pp. 2494-2498 ◽  
Author(s):  
Sri Krishna Nimmagadda ◽  
Sharath Chandra Mallojjala ◽  
Lukasz Woztas ◽  
Steven E. Wheeler ◽  
Jon C. Antilla
Keyword(s):  
Kinetic Resolution ◽  
Enantioselective Synthesis ◽  
Dynamic Kinetic Resolution

Enantioselective Synthesis of (R)-Bufuralol via Dynamic Kinetic Resolution in the Key Step

2010 ◽  
Vol 75 (13) ◽  
pp. 4596-4599 ◽  
Author(s):  
Eric V. Johnston ◽  
Krisztián Bogár ◽  
Jan-E. Bäckvall
Keyword(s):  
Kinetic Resolution ◽  
Enantioselective Synthesis ◽  
Dynamic Kinetic Resolution

Dynamic Kinetic Resolution and Desymmetrization Processes: A Straightforward Methodology for the Enantioselective Synthesis of Piperidines.

ChemInform ◽  
2007 ◽  
Vol 38 (6) ◽  
Author(s):  
Mercedes Amat ◽  
Oriol Bassas ◽  
Nuria Llor ◽  
Margalida Canto ◽  
Maria Perez ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Enantioselective Synthesis ◽  
Dynamic Kinetic Resolution

Chemoenzymatic dynamic kinetic resolution as a key step in the enantioselective synthesis of (S)-salbutamol

2011 ◽  
Vol 76 (7) ◽  
pp. 919-927 ◽  
Author(s):  
Annika Träff ◽  
Carmen E. Solarte ◽  
Jan-E. Bäckvall
Keyword(s):  
Burkholderia Cepacia ◽  
Kinetic Resolution ◽  
Enantiomeric Excess ◽  
Enantioselective Synthesis ◽  
Dynamic Kinetic Resolution

The synthesis of (S)-salbutamol is described. By utilizing DKR in the enantiodetermining step, employing Burkholderia cepacia lipase (PS-IM), (S)-acetate ((S)-6) was obtained in excellent enantiomeric excess (98%). The subsequent transformations yielded the salt of (S)-salbutamol with retained stereochemistry.

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