Structure–Activity Relationships by NMR: A New Procedure for Drug Discovery by a Combinatorial–Rational Approach

1997 ◽  
Vol 36 (8) ◽  
pp. 829-831 ◽  
Author(s):  
Horst Kessler
Keyword(s):  
Drug Discovery ◽  
Rational Approach ◽  
Structure Activity Relationships ◽  
Structure Activity

Large Compound Databases for Structure-Activity Relationships Studies in Drug Discovery

2007 ◽  
Vol 7 (8) ◽  
pp. 851-860 ◽  
Author(s):  
Thomas Scior ◽  
Philippe Bernard ◽  
Jose Luis Medina-Franco ◽  
Gerald. M. Maggiora
Keyword(s):  
Drug Discovery ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Large Compound

Peptide Scanning for Studying Structure-Activity Relationships in Drug Discovery

2012 ◽  
Vol 81 (1) ◽  
pp. 148-165 ◽  
Author(s):  
Andrew G. Jamieson ◽  
Nicolas Boutard ◽  
David Sabatino ◽  
William D. Lubell
Keyword(s):  
Drug Discovery ◽  
Structure Activity Relationships ◽  
Structure Activity

Molecular Diversity and Libraries of Structures: Synthesis and Screening

1996 ◽  
Vol 61 (2) ◽  
pp. 171-231 ◽  
Author(s):  
Markéta Rinnová ◽  
Michal Lebl
Keyword(s):  
Drug Discovery ◽  
Rational Design ◽  
Molecular Diversity ◽  
Molecular Structures ◽  
The Other ◽  
Biological Assay ◽  
Rapid Evaluation ◽  
Biological Interactions ◽  
Structure Activity Relationships ◽  
Structure Activity

Library, or molecular diversity, approaches are a progressive tool in contemporary investigation of biological interactions and drug discovery. All library approaches include certain degree of rationality and cannot be therefore classified as random or irrational techniques. Reviewed techniques are complementary to so called "rational design"; they can serve either as a tool to generate a lead, or, on the other hand, to optimize a "designed" lead by rapid evaluation of structure-activity relationships. Combinatorial approaches are based on either a random or multiple principle which enables production of large number of diverse molecular structures that can be simultaneously screened and evaluated in a biological assay to find an optimal interacting molecule.

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