Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure–Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents

Marco Pieroni; Elisa Azzali; Nicoletta Basilico; Silvia Parapini; Michal Zolkiewski; Claudia Beato; Giannamaria Annunziato; Agostino Bruno; Federica Vacondio; Gabriele Costantino

doi:10.1021/acs.jmedchem.6b01685

Accepting the Invitation to Open Innovation in Malaria Drug Discovery: Synthesis, Biological Evaluation, and Investigation on the Structure–Activity Relationships of Benzo[b]thiophene-2-carboxamides as Antimalarial Agents

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b01685 ◽

2017 ◽

Vol 60 (5) ◽

pp. 1959-1970 ◽

Cited By ~ 31

Author(s):

Marco Pieroni ◽

Elisa Azzali ◽

Nicoletta Basilico ◽

Silvia Parapini ◽

Michal Zolkiewski ◽

...

Keyword(s):

Drug Discovery ◽

Open Innovation ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Antimalarial Agents ◽

Structure Activity

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Structure–activity relationships of hydroxamate-based histone deacetylase-8 inhibitors: reality behind anticancer drug discovery

Future Medicinal Chemistry ◽

10.4155/fmc-2017-0130 ◽

2017 ◽

Vol 9 (18) ◽

pp. 2211-2237 ◽

Cited By ~ 21

Author(s):

Sk Abdul Amin ◽

Nilanjan Adhikari ◽

Tarun Jha

Keyword(s):

Drug Discovery ◽

Histone Deacetylase ◽

Anticancer Drug ◽

Structure Activity Relationships ◽

Structure Activity ◽

Histone Deacetylase 8 ◽

Anticancer Drug Discovery

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Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 18.1N-Substituted 14-Phenylpropyloxymorphinan-6-ones with Unanticipated Agonist Properties: Extending the Scope of Common Structure−Activity Relationships

Journal of Medicinal Chemistry ◽

10.1021/jm021118o ◽

2003 ◽

Vol 46 (9) ◽

pp. 1758-1763 ◽

Cited By ~ 23

Author(s):

Elisabeth Greiner ◽

Mariana Spetea ◽

Roland Krassnig ◽

Falko Schüllner ◽

Mario Aceto ◽

...

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Common Structure ◽

Structure Activity ◽

Synthesis And Biological Evaluation

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125 Synthesis, biological evaluation and structure activity relationships of a novel servies of aromatic hydroxamic acids as potent HDAC inhibitors

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(04)80133-2 ◽

2004 ◽

Vol 2 (8) ◽

pp. 40-41

Author(s):

K. Van Emelen ◽

J. Arts ◽

P. Angibaud ◽

H. De Winter ◽

S. Van Brandt ◽

...

Keyword(s):

Hdac Inhibitors ◽

Hydroxamic Acids ◽

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity

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Biological Evaluation, Structure−Activity Relationships, and Three-Dimensional Quantitative Structure−Activity Relationship Studies of Dihydro-β-agarofuran Sesquiterpenes as Modulators of P-Glycoprotein-Dependent Multidrug Resistance

Journal of Medicinal Chemistry ◽

10.1021/jm070290v ◽

2007 ◽

Vol 50 (20) ◽

pp. 4808-4817 ◽

Cited By ~ 30

Author(s):

Carolina P. Reyes ◽

Francisco Muñoz-Martínez ◽

Ivan R. Torrecillas ◽

Cristina R. Mendoza ◽

Francisco Gamarro ◽

...

Keyword(s):

Multidrug Resistance ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

P Glycoprotein

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Structure–Activity Relationships by NMR: A New Procedure for Drug Discovery by a Combinatorial–Rational Approach

Angewandte Chemie International Edition in English ◽

10.1002/anie.199708291 ◽

1997 ◽

Vol 36 (8) ◽

pp. 829-831 ◽

Cited By ~ 15

Author(s):

Horst Kessler

Keyword(s):

Drug Discovery ◽

Rational Approach ◽

Structure Activity Relationships ◽

Structure Activity

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Selective and effective anticancer agents: Synthesis, biological evaluation and structure-activity relationships of novel carbazole derivatives

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104991 ◽

2021 ◽

pp. 104991

Author(s):

Wenbo Huang ◽

Zilin Gao ◽

Zhigang Zhang ◽

Wei Fang ◽

Zuoqian Wang ◽

...

Keyword(s):

Anticancer Agents ◽

Biological Evaluation ◽

Carbazole Derivatives ◽

Structure Activity Relationships ◽

Structure Activity

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Aryl piperazine and pyrrolidine as antimalarial agents. Synthesis and investigation of structure–activity relationships

Experimental Parasitology ◽

10.1016/j.exppara.2011.02.025 ◽

2011 ◽

Vol 128 (2) ◽

pp. 97-103 ◽

Cited By ~ 22

Author(s):

Adela Mendoza ◽

Silvia Pérez-Silanes ◽

Miguel Quiliano ◽

Adriana Pabón ◽

Silvia Galiano ◽

...

Keyword(s):

Structure Activity Relationships ◽

Antimalarial Agents ◽

Structure Activity

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Synthesis, Biological Evaluation, and Structure−Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2

Journal of Medicinal Chemistry ◽

10.1021/jm960863w ◽

1997 ◽

Vol 40 (17) ◽

pp. 2694-2705 ◽

Cited By ~ 20

Author(s):

Matthias Lehr

Keyword(s):

Phospholipase A2 ◽

Carboxylic Acids ◽

Biological Evaluation ◽

Cytosolic Phospholipase A2 ◽

Structure Activity Relationships ◽

Cytosolic Phospholipase ◽

Structure Activity

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Taxol structure-activity relationships: synthesis and biological evaluation of 10-deoxytaxol

The Journal of Organic Chemistry ◽

10.1021/jo00063a001 ◽

1993 ◽

Vol 58 (11) ◽

pp. 2927-2928 ◽

Cited By ~ 32

Author(s):

Shu Hui Chen ◽

Craig Fairchild ◽

Stephen W. Mamber ◽

Vittorio Farina

Keyword(s):

Biological Evaluation ◽

Structure Activity Relationships ◽

Structure Activity ◽

Synthesis And Biological Evaluation

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New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: Design, synthesis, structure–activity relationships and biological evaluation

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.08.011 ◽

2013 ◽

Vol 68 ◽

pp. 433-443 ◽

Cited By ~ 20

Author(s):

Sébastien Fortin ◽

Kevin Brasseur ◽

Nathalie Morin ◽

Éric Asselin ◽

Gervais Bérubé

Keyword(s):

Prostate Cancer ◽

Biological Evaluation ◽

Design Synthesis ◽

Structure Activity Relationships ◽

Structure Activity

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