Enantiodivergent Atroposelective Synthesis of Chiral Biaryls by Asymmetric Transfer Hydrogenation: Chiral Phosphoric Acid Catalyzed Dynamic Kinetic Resolution

2016 ◽  
Vol 55 (38) ◽  
pp. 11642-11646 ◽  
Author(s):  
Keiji Mori ◽  
Tsubasa Itakura ◽  
Takahiko Akiyama
Keyword(s):  
Phosphoric Acid ◽  
Kinetic Resolution ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines

2014 ◽  
Vol 50 (83) ◽  
pp. 12526-12529 ◽  
Author(s):  
Mu-Wang Chen ◽  
Xian-Feng Cai ◽  
Zhang-Pei Chen ◽  
Lei Shi ◽  
Yong-Gui Zhou
Keyword(s):  
Phosphoric Acid ◽  
Kinetic Resolution ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Resolution Process ◽  
Chiral Phosphoric Acid ◽  
Stereogenic Centers ◽  
Facile Route

An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.

Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines

2016 ◽  
Vol 14 (29) ◽  
pp. 6937-6941 ◽  
Author(s):  
Ji Zhou ◽  
Qian-Fan Zhang ◽  
Wei-Hao Zhao ◽  
Guo-Fang Jiang
Keyword(s):  
Phosphoric Acid ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

A chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of 3-trifluoromethylthioquinolines was developed, providing chiral 2,3-disubstituted 1,2,3,4-tetrahydroquinoline derivatives containing a stereogenic trifluoromethylthio group with up to 99% enantioselectivity.

Chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation of quinazolinones

2019 ◽  
Vol 60 (33) ◽  
pp. 150947
Author(s):  
Fan-Jie Meng ◽  
Lei Shi ◽  
Wen-Feng Jiang ◽  
Guang-Shou Feng ◽  
Xiao-Bing Lu ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

scholarly journals Chiral Phosphoric Acid-Catalyzed Asymmetric Transfer Hydrogenation of Quinolin-3-amines

2014 ◽  
Vol 16 (10) ◽  
pp. 2680-2683 ◽  
Author(s):  
Xian-Feng Cai ◽  
Ran-Ning Guo ◽  
Guang-Shou Feng ◽  
Bo Wu ◽  
Yong-Gui Zhou
Keyword(s):  
Phosphoric Acid ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

scholarly journals Redox deracemization of β,γ-alkynyl α-amino esters

2020 ◽  
Vol 11 (17) ◽  
pp. 4444-4449 ◽  
Author(s):  
Lu Zhang ◽  
Rongxiu Zhu ◽  
Aili Feng ◽  
Changyin Zhao ◽  
Lei Chen ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Aerobic Oxidation ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
One Pot ◽  
Amino Esters ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

A one-pot deracemization of β,γ-alkynyl α-amino esters consisting of an aerobic oxidation and chiral phosphoric acid-catalyzed asymmetric transfer hydrogenation has been described.

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