Frontispiece: Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

Sulfonamide-linked glycoclusters and sulfamate-linked BSA-PEG were prepared by coupling a sugar sulfonyl fluoride with a calixarene tetra-amine and a PEG-fluorosulfate with native bovine serum albumin, respectively.

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Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

ACS Chemical Biology ◽

10.1021/cb5009475 ◽

2015 ◽

Vol 10 (4) ◽

pp. 1094-1098 ◽

Cited By ~ 81

Author(s):

Erik C. Hett ◽

Hua Xu ◽

Kieran F. Geoghegan ◽

Ariamala Gopalsamy ◽

Robert E. Kyne ◽

...

Keyword(s):

Active Site ◽

Tyrosine Residues ◽

Active Site Tyrosine ◽

Sulfonyl Fluoride

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Sulfonyl Fluoride Inhibitors of Fatty Acid Amide Hydrolase

Journal of Medicinal Chemistry ◽

10.1021/jm301205j ◽

2012 ◽

Vol 55 (22) ◽

pp. 10074-10089 ◽

Cited By ~ 20

Author(s):

Shakiru O. Alapafuja ◽

Spyros P. Nikas ◽

Indu T. Bharathan ◽

Vidyanand G. Shukla ◽

Mahmoud L. Nasr ◽

...

Keyword(s):

Fatty Acid ◽

Fatty Acid Amide Hydrolase ◽

Acid Amide ◽

Amide Hydrolase ◽

Sulfonyl Fluoride ◽

Fatty Acid Amide

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Irreversible enzyme inhibitors. CLI. Active-site-directed irreversible inhibitors of dihydrofolic reductase derived from 5-(p-aminophenylbutyl)-2,4-diaminopyrimidines with a terminal phenylene sulfonyl fluoride

Journal of Medicinal Chemistry ◽

10.1021/jm00302a007 ◽

1969 ◽

Vol 12 (2) ◽

pp. 224-227 ◽

Cited By ~ 1

Author(s):

Bernard Randall Baker ◽

Rich B. Meyer

Keyword(s):

Active Site ◽

Enzyme Inhibitors ◽

Irreversible Inhibitors ◽

Sulfonyl Fluoride

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Hemolytic and Elastolytic Activities Influenced by Iron in Plesiomonas shigelloides

Journal of Food Protection ◽

10.4315/0362-028x-62.12.1475 ◽

1999 ◽

Vol 62 (12) ◽

pp. 1475-1477 ◽

Cited By ~ 19

Author(s):

JESÚS A. SANTOS ◽

CÉSAR J. GONZÁLEZ ◽

TERESA M. LÓPEZ ◽

ANDRÉS OTERO ◽

MARÍA-LUISA GARCÍA-LÓPEZ

Keyword(s):

Thermal Treatment ◽

Hemolytic Activity ◽

Serine Proteases ◽

Culture Media ◽

Plesiomonas Shigelloides ◽

Elastin Degradation ◽

Elastolytic Activity ◽

Degradation Activity ◽

Phenylmethyl Sulfonyl Fluoride ◽

Sulfonyl Fluoride

The aim of this study was to determine the presence of hemolytic and elastolytic enzymes in several strains of Plesiomonas shigelloides in relation to the availability of iron in culture media. Hemolytic activity and elastolytic activity were detected in strains of P. shigelloides and were enhanced when the strains were grown in an iron-depleted medium and lost after thermal treatment at 100°C for 10 min. Also, elastolytic activity was inactivated by phenylmethyl sulfonyl fluoride, an inhibitor of serine proteases. Hemolytic activity was detected extracellularly in cell-free supernatants, whereas elastin degradation activity was cell associated. Both activities may be related to the virulence of P. shigelloides.

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