Transition metal complexes of a novel quinoxaline-based tridentate ONO donor ligand: synthesis, spectral characterization, thermal,in vitropharmacological and molecular modeling studies

2016 ◽  
Vol 30 (10) ◽  
pp. 860-871 ◽  
Author(s):  
Chellaian Justin Dhanaraj ◽  
Jijo Johnson
Keyword(s):  
Molecular Modeling ◽  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Spectral Characterization ◽  
Donor Ligand ◽  
Modeling Studies ◽  
Molecular Modeling Studies ◽  
Ligand Synthesis

scholarly journals Spectral Characterization and 3D Molecular Modeling Studies of Metal Complexes Involving the O, N-Donor Environment of Quinazoline-4(3H)-one Schiff Base and Their Biological Studies

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Kuruba Siddappa ◽  
Sunilkumar B. Mane ◽  
Deene Manikprabhu
Keyword(s):  
Schiff Base ◽  
Molecular Modeling ◽  
Metal Complexes ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Spectral Characterization ◽  
Magnetic Data ◽  
Modeling Studies ◽  
Biological Studies ◽  
Molecular Modeling Studies

A simple condensation of 3-amino-2-methylquinazoline-4-one with 2-hydroxy-1-naphthaldehyde produced new tridentate ONO donor Schiff base ligand with efficient yield. The structural characterization of ligand and its Cu(II), Ni(II), Co(II), Mn(II), Zn(II), and Cd(II) complexes were achieved by the aid of elemental analysis, spectral characterization such as (UV-visible, IR, NMR, mass, and ESR), and magnetic data. The analytical and spectroscopic studies suggest the octahedral geometries of Cu(II), Co(II), Ni(II) and Mn(II) complexes and tetrahedral geometry of Zn(II) and Cd(II) complexes with the tridentate ONO Schiff base ligand. Furthermore, the conclusions drawn from these studies afford further support to the mode of bonding discussed on the basis of their 3D molecular modeling studies by considering different bond lengths, bond angles, and bond distance. The ligand and its metal complexes evaluated for their antimicrobial activity againstStaphylococcus aureus(MTCC number 7443),Bacillus subtilis(MTCC number 9878),Escherichia coli(MTCC number 1698),Aspergillus niger(MTCC number 281), andAspergillus flavus(MTCC number 277). The MIC of these compounds was found to be most active at 10 μg/mL concentration in inhibiting the growth of the tested organisms. The DNA cleavage activity of all the complexes was studied by gel electrophoresis method.

Structure, biological and electrochemical studies of transition metal complexes from N,S,N′ donor ligand 8-(2-pyridinylmethylthio)quinoline

Polyhedron ◽  
2010 ◽  
Vol 29 (1) ◽  
pp. 581-591 ◽  
Author(s):  
Jing-An Zhang ◽  
Mei Pan ◽  
Rui Yang ◽  
Zhi-Gang She ◽  
Wolfgang Kaim ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Electrochemical Studies ◽  
Donor Ligand
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