Ferrocenecarbaldehyde isonicotinyl hydrazide

2004 ◽  
Vol 18 (9) ◽  
pp. 438-439 ◽  
Author(s):  
Zhen-Feng Chen ◽  
Hong-Li Zou ◽  
Hong Liang ◽  
Rong-Xin Yuan ◽  
Yong Zhang
Keyword(s):  
Isonicotinyl Hydrazide

The photoassimilation of glucose in Chlorella with reference to the role of glycollic acid

1966 ◽  
Vol 165 (1001) ◽  
pp. 473-485 ◽  
Keyword(s):  
Chlorella Pyrenoidosa ◽  
Chain Formation ◽  
Glycollic Acid ◽  
Isonicotinyl Hydrazide

The photometabolism of glucose by Chlorella pyrenoidosa was studied by following the fate of exogenously supplied glucose-1- 14 C, glucose-2- 14 C and glucose-6- 14 C. The sucrose and insoluble polyglucan formed were extracted and hydrolysed. The constituent glucose units were degraded to determine the distribution of radioactivity between the six carbon atoms of the glucose chain. Formation of glycollic acid and of glycine was stimulated by a gas stream of 100% oxygen and by adding isonicotinyl hydrazide ( INH ). Although increases of glycollic acid and glycine were observed as a result of these treatments and at the expense of both sucrose and polyglucan the distribution of 14 C between the carbon atoms of the glucose units was scarcely affected. The results are discussed with particular reference to the metabolism of glycollic acid in Chlorella .

Colorimetric Determination of the Progestational Steroids in Contraceptive Tablets

1970 ◽  
Vol 53 (4) ◽  
pp. 831-833
Author(s):  
John Y P Wu
Keyword(s):  
Oral Contraceptive ◽  
Medroxyprogesterone Acetate ◽  
Collaborative Study ◽  
Chloroform Extract ◽  
Colorimetric Determination ◽  
Standard Deviations ◽  
Isonicotinyl Hydrazide ◽  
Norethindrone Acetate

Abstract Norethindrone, norethindrone acetate, dimethisterone, medroxyprogesterone acetate, and norethynodrel are determined in oral contraceptive tablets. For the first 4 compounds, a chloroform extract of the tablets is treated directly with isonicotinyl hydrazide reagent to produce a stable color which is measured at 380 nm. The chloroform extract of norethynodrel tablets is isomerized before the reagent is added. An intralaboratory study gave good results, with standard deviations of 0.74 to 1.21%. A collaborative study is recommended.

THE ESTIMATION OF ISONICOTINYL HYDRAZIDE

1952 ◽  
Vol 4 (1) ◽  
pp. 687-692 ◽  
Author(s):  
E. A. Haugas ◽  
B. W. Mitchell
Keyword(s):  
Isonicotinyl Hydrazide

Inhibition by isonicotinyl hydrazide of pigment formation in higher plants

1974 ◽  
Vol 13 (9) ◽  
pp. 1657-1665 ◽  
Author(s):  
Michael G. Gore ◽  
Howard M. Hill ◽  
Brian Evans ◽  
Lyndon J. Rogers
Keyword(s):  
Higher Plants ◽  
Pigment Formation ◽  
Isonicotinyl Hydrazide

Maleic Hydrazide and Isonicotinyl Hydrazide as Carbonyl Reagents

1966 ◽  
Vol 19 (2) ◽  
pp. 257-263 ◽  
Author(s):  
Yonezo Suzuki
Keyword(s):  
Maleic Hydrazide ◽  
Isonicotinyl Hydrazide

The mechanism of the inhibition of decarboxylases by ISOnicotinyl hydrazide

1956 ◽  
Vol 19 ◽  
pp. 131-140 ◽  
Author(s):  
A.N. Davison
Keyword(s):  
Isonicotinyl Hydrazide

The Effect of Isoniazid on Depressive States

1955 ◽  
Vol 101 (424) ◽  
pp. 564-568
Author(s):  
A. J. Oldham
Keyword(s):  
Depressive Disorders ◽  
Direct Action ◽  
Toxic Effects ◽  
Therapeutic Action ◽  
Affective Component ◽  
The Central Nervous System ◽  
Initial Survey ◽  
Isonicotinyl Hydrazide ◽  
Higher Doses ◽  
Depressive States

Isonicotinyl Hydrazide or Isoniazid has for some years now been used in conjunction with other compounds in the treatment of pulmonary tuberculosis. During this treatment certain workers (Robitzek et al., 1952) noted the development of a state of euphoria in their patients. Since Isoniazid was known to exert toxic effects on nervous tissue (Gammen et al., 1953) the hypothesis was made that the substance might be capable of producing an elevation of mood by direct action on the central nervous system. Acting on this hypothesis, Salzer and Lurie (1953) treated a group of patients suffering from various depressive conditions with Isoniazid given orally in the dosage of 50 mgm. t.d.s. for one week. If no toxic effects occurred the dosage was raised to 100 mgm. t.d.s. for a further two weeks, while in a few cases only higher doses were given. These workers maintained this level of dosage in order to avoid the advent of toxic side effects. Their results, which will be discussed later in this paper, led them to the conclusion that isoniazid had a specific therapeutic effect upon certain depressive disorders.The object of this study, arising out of the work mentioned, was to carry out an initial survey of the effects of isoniazid on the affective component of various depressive states. If any demonstrable therapeutic action had been noted a larger, controlled, and more systematic study would have been undertaken but in view of the results obtained this further project has now been abandoned.

Stimulation of Photorespiration by the Carbonic Anhydrase Inhibitor Ethoxyzolamide in Chlorella vulgaris

1986 ◽  
Vol 41 (5-6) ◽  
pp. 564-570 ◽  
Author(s):  
Yoshihiro Shiraiwa ◽  
Georg H. Schmid
Keyword(s):  
Carbonic Anhydrase ◽  
Partial Pressure ◽  
Ammonia Excretion ◽  
Methionine Sulfoximine ◽  
Bisphosphate Carboxylase ◽  
High Ammonia ◽  
Glycolate Dehydrogenase ◽  
Qualitative Effect ◽  
Isonicotinyl Hydrazide ◽  
Stimulation Of

Ammonia was excreted at high rates in the presence of L-methionine sulfoximine (L-MSO) from Chlorella cells which have been grown and analyzed at normal CO2 partial pressure (330 ppm ). If these cells are analyzed at high CO2-concentration (3% CO2 in air) only little ammonia is excreted in the presence of L-MSO. In the absence of L-MSO no ammonia is excreted under either condition. In agreem ent with this observation Chlorella cells grown under high CO2 partial pressure (3% CO2 in air) but tested under normal CO2 partial pressure excreted only very little ammonia. Under these conditions neither “High CO2-cells” nor “Low CO2-cells” exhibited any glycolate excretion. However, glycolate excretion was observed in the presence of a-HPMS (a-hydroxy-2-pyridyl methanesulfonate) an inhibitor of glycolate dehydrogenase or INH (isonicotinyl hydrazide) an inhibitor of the glycine-serine am inotransferase, irrespective of the presence or absence of L-M SO. INH inhibited ammonia excretion. The above described high ammonia excretion in “Low CO2-cells” in the presence of L-MSO was suppressed or substantially reduced by 0.1 mм ethoxyzolamide an inhibitor of carbonic anhydrase which, however, at the same time caused a substantial excretion of glycolate into the medium. The same qualitative effect of ethoxyzolam ide was observed in “High CO2-cells” (tested under normal CO2 partial pressure) although the amount of glycolate excreted in this type of culture was very small. It was generally noted that glycolate excretion caused by ethoxyzolamide was stoichiometrically always more important than the rate of ammonia excretion which was inhibited. This shows that excretion and therefore most probably also the formation of glycolate are enhanced by ethoxyzolamide. The experiments seem to show that due to the inhibition of carbonic anhydrase the affinity of the ribulose-1,5-bisphosphate carboxylase/oxygenase system is increased towards oxygen, which leads to a stimulation of the photorespiratory carbon cycle.

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