Developmental toxicity evaluation of sodium thioglycolate administered topically to Sprague-Dawley (CD) rats and New Zealand white rabbits

2003 ◽  
Vol 68 (2) ◽  
pp. 144-161 ◽  
Author(s):  
R.W. Tyl ◽  
C.J. Price ◽  
M.C. Marr ◽  
C.B. Myers ◽  
A.P.J.M. van Birgelen ◽  
...  
Keyword(s):  
New Zealand ◽  
Developmental Toxicity ◽  
Sprague Dawley ◽  
Toxicity Evaluation ◽  
New Zealand White Rabbits

Reproductive and developmental toxicity assessment of palbociclib, a CDK4/6 inhibitor, in Sprague-Dawley rats and New Zealand White rabbits

2019 ◽  
Vol 88 ◽  
pp. 76-84 ◽  
Author(s):  
N.R. Catlin ◽  
C.J. Bowman ◽  
S.M. Engel ◽  
A. Sacaan ◽  
S. Thibault ◽  
...  
Keyword(s):  
New Zealand ◽  
Developmental Toxicity ◽  
Toxicity Assessment ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
New Zealand White Rabbits

scholarly journals Evaluation of the Developmental Toxicity of Methacrylonitrile in Sprague-Dawley Rats and New Zealand White Rabbits

1996 ◽  
Vol 34 (2) ◽  
pp. 249-259
Author(s):  
JULIA D. GEORGE ◽  
CATHERINE J. PRICE ◽  
MELISSA C. MARR ◽  
CHRISTINA B. MYERS ◽  
BERNARD A. SCHWETZ ◽  
...  
Keyword(s):  
New Zealand ◽  
Developmental Toxicity ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
New Zealand White Rabbits

Developmental Toxicity Evaluation of Inhaled 2–Ethoxyethanol Acetate in Ficher 344 Rats and New Zealand White Rabbits

1988 ◽  
Vol 10 (1) ◽  
pp. 20-39
Author(s):  
R. W. TYL ◽  
I. M. PRITTS ◽  
K. A. FRANCES ◽  
L. C. FISHER ◽  
T. R. TYLER
Keyword(s):  
New Zealand ◽  
Developmental Toxicity ◽  
Toxicity Evaluation ◽  
New Zealand White Rabbits

Developmental Toxicity Evaluation of Ethylene Glycol by Gavage in New Zealand White Rabbits

1993 ◽  
Vol 20 (4) ◽  
pp. 402-412
Author(s):  
ROCHELLE W. TYL ◽  
CATHERINE J. PRICE ◽  
MELISSA C. MARR ◽  
CHRISTINA B. MYERS ◽  
JOHN C. SEELY ◽  
...  
Keyword(s):  
New Zealand ◽  
Ethylene Glycol ◽  
Developmental Toxicity ◽  
Toxicity Evaluation ◽  
New Zealand White Rabbits

Developmental Toxicity of Cumene Vapor in Cd Rats and New Zealand White Rabbits

1997 ◽  
Vol 16 (2) ◽  
pp. 119-139 ◽  
Author(s):  
Kenneth I. Darmer ◽  
Teresa L. Neeper-Bradley ◽  
Janette R. Cushman ◽  
Carl R. Morris ◽  
Barbara O. Francis
Keyword(s):  
Body Weight ◽  
Weight Gain ◽  
New Zealand ◽  
Food Consumption ◽  
Body Weight Gain ◽  
Developmental Toxicity ◽  
Exposure Period ◽  
Exposure Level ◽  
Sprague Dawley ◽  
New Zealand White Rabbits

The potential developmental toxicity of cumene vapor (99.9% pure) was assessed in pregnant CD (Sprague-Dawley) rats and New Zealand White rabbits exposed for 6 h per day by inhalation, the most relevant route of potential human exposure. Groups of 25 rats were exposed on gestational days (GD) 6–15 to concentrations of 0 (filtered air), 100, 500, or 1200 ppm, and groups of 15 rabbits were exposed on GD 6–18 to 0, 500, 1200, and 2300 ppm cumene vapor. In rats, reduced maternal body weight gain and increased relative liver weight was observed at 1200 ppm cumene. In rats and rabbits, reduced food consumption was observed at concentrations of 500 and 1200 ppm. A t 2300 ppm, 2 rabbits died, body weight gain and food consumption were reduced during the exposure period, and relative liver weights were increased. None of the gestational parameters, including numbers of viable implantations per litter, sex ratio, and fetal body weights, were affected at any exposure level in rats or rabbits. There were no treatment-related increases in incidences of external, visceral, or skeletal malformations or in the incidences of variations at any level. Thus, in rats, the no observable adverse effect level (NO A EL) for maternal toxicity was 100 ppm and the NO A EL for developmental toxicity was 1200 ppm, the highest concentration of cumene vapor tested. In rabbits, there was no NO A EL for maternal toxicity, but the NO A EL for developmental toxicity was 2300 ppm for cumene, the highest concentration tested. Therefore, even at exposure levels associated with maternal toxicity, cumene was not a developmental toxicant by inhalation exposure in either rats or rabbits.

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