Enteric glial cells. An upstream target for induction of necrotizing enterocolitis and Crohn's disease?

BioEssays ◽  
2002 ◽  
Vol 24 (2) ◽  
pp. 130-140 ◽  
Author(s):  
Toby G. Bush
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Necrotizing Enterocolitis ◽  
Glial Cells ◽  
Enteric Glial Cells

scholarly journals The multiple faces of inflammatory enteric glial cells: is Crohn’s disease a gliopathy?

2018 ◽  
Vol 315 (1) ◽  
pp. G1-G11 ◽  
Author(s):  
Camille Pochard ◽  
Sabrina Coquenlorge ◽  
Marie Freyssinet ◽  
Philippe Naveilhan ◽  
Arnaud Bourreille ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Glial Cells ◽  
Physiological Role ◽  
Enteric Neurons ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Enteric Glial Cells ◽  
Glial Reactivity

Gone are the days when enteric glial cells (EGC) were considered merely satellites of enteric neurons. Like their brain counterpart astrocytes, EGC express an impressive number of receptors for neurotransmitters and intercellular messengers, thereby contributing to neuroprotection and to the regulation of neuronal activity. EGC also produce different soluble factors that regulate neighboring cells, among which are intestinal epithelial cells. A better understanding of EGC response to an inflammatory environment, often referred to as enteric glial reactivity, could help define the physiological role of EGC and the importance of this reactivity in maintaining gut functions. In chronic inflammatory disorders of the gut such as Crohn’s disease (CD) and ulcerative colitis, EGC exhibit abnormal phenotypes, and their neighboring cells are dysfunctional; however, it remains unclear whether EGC are only passive bystanders or active players in the pathophysiology of both disorders. The aim of the present study is to review the physiological roles and properties of EGC, their response to inflammation, and their role in the regulation of the intestinal epithelial barrier and to discuss the emerging concept of CD as an enteric gliopathy.

scholarly journals Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn’s Disease

2016 ◽  
Vol 150 (1) ◽  
pp. 168-180 ◽  
Author(s):  
Camille Pochard ◽  
Sabrina Coquenlorge ◽  
Julie Jaulin ◽  
Nicolas Cenac ◽  
Nathalie Vergnolle ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Glial Cells ◽  
Epithelial Permeability ◽  
Enteric Glial Cells ◽  
And Control

DOP23 Myenteric plexitis and post-operative recurrence in Crohn’s disease: the role of enteric glial cells and ICAM-1

2019 ◽  
Vol 13 (Supplement_1) ◽  
pp. S038-S039
Author(s):  
C Le Berre ◽  
J Pabois ◽  
T Durand ◽  
E Durieu ◽  
M Rolli-Derkinderen ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Glial Cells ◽  
Enteric Glial Cells

scholarly journals Enterocolitis induced by autoimmune targeting of enteric glial cells: A possible mechanism in Crohn's disease?

2001 ◽  
Vol 98 (23) ◽  
pp. 13306-13311 ◽  
Author(s):  
A. Cornet ◽  
T. C. Savidge ◽  
J. Cabarrocas ◽  
W.-L. Deng ◽  
J.-F. Colombel ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Glial Cells ◽  
Enteric Glial Cells

scholarly journals Gene expression profiling in necrotizing enterocolitis reveals pathways common to those reported in Crohn’s disease

2015 ◽  
Vol 9 (1) ◽  
Author(s):  
Éric Tremblay ◽  
Marie-Pier Thibault ◽  
Emanuela Ferretti ◽  
Corentin Babakissa ◽  
Valérie Bertelle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Gene Expression Profiling ◽  
Necrotizing Enterocolitis ◽  
Expression Profiling

On-table endoscopy to define strictures and resection margins: experience from 178 operations for Crohn's disease using intraoperative endoscopy

2001 ◽  
Vol 3 (Supplement 2) ◽  
pp. 58-62
Author(s):  
G. Olaison ◽  
P. Andersson ◽  
P. Myrelid ◽  
K. Smedh ◽  
J. Soderholm ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Resection Margins ◽  
Intraoperative Endoscopy
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