Simultaneous densitometric determination of anthelmintic drug albendazole and its metabolite albendazole sulfoxide by HPTLC in human plasma and pharmaceutical formulations

2017 ◽  
Vol 31 (9) ◽  
pp. e3947 ◽  
Author(s):  
Jui J. Pandya ◽  
Mallika Sanyal ◽  
Pranav S. Shrivastav
Keyword(s):  
Human Plasma ◽  
Pharmaceutical Formulations ◽  
Anthelmintic Drug ◽  
Albendazole Sulfoxide

scholarly journals LC-MS/MS method for the determination of diazolic anthelmintic drug levels from sheep and human plasma for use in pharmacokinetic and bioavailability studies

2021 ◽  
Vol 66 (1) ◽  
pp. 181-194
Author(s):  
Lénárd Farczádi ◽  
◽  
Silvia Imre ◽  
Laurian Vlase ◽  
◽  
...  
Keyword(s):  
Human Plasma ◽  
Drug Levels ◽  
Anthelmintic Drug

Sensitive enantioseparation and determination of isoprenaline in human plasma and pharmaceutical formulations

2019 ◽  
pp. e4550 ◽  
Author(s):  
Vinod Kumar Vashistha ◽  
Ravi Bhushan
Keyword(s):  
Human Plasma ◽  
Pharmaceutical Formulations

scholarly journals Spectrofluorometric Determination of Verapamil Hydrochloride in Pharmaceutical Preparations and Human Plasma Using Organized Media: Application to Stability Studies

2006 ◽  
Vol 89 (6) ◽  
pp. 1565-1572 ◽  
Author(s):  
Mohamed Walash ◽  
Fathalla Belal ◽  
Nahed El-Enany ◽  
Amina Abdelsalam
Keyword(s):  
Human Plasma ◽  
Biological Fluids ◽  
Sodium Dodecyl ◽  
Pharmaceutical Preparations ◽  
Pharmaceutical Formulations ◽  
Official Method ◽  
Stability Studies ◽  
Verapamil Hydrochloride ◽  
Spiked Human Plasma

Abstract A highly sensitive spectrofluorometric method was developed for the determination of verapamil hydrochloride (VP HCl) in pharmaceutical formulations and biological fluids. The proposed method is based on investigation of the fluorescence spectral behavior of VP HCl in micellar systems, such as sodium dodecyl sulfate (SDS) and β-cyclodextrin (β-CD). In aqueous solutions of borate buffer of pH 9 and 8.5, VP HCl was well incorporated into SDS and β-CD, respectively, with enhancement of its native fluorescence. The fluorescence was measured at 318 nm after excitation at 231 nm. The fluorescence intensity enhancements were 183 and 107% in SDS and in β-CD, respectively. The fluorescence-concentration plots were rectilinear over the range of 0.020.2 and 0.020.25 μg/mL, with lower detection limits of 5.58 × 103 and 3.62 × 103 μg/mL in SDS and β-CD, respectively. The method was successfully applied to the analysis of commercial tablets and the results were in good agreement with those obtained with the official method. The method was further applied to the determination of VP HCl in real and spiked human plasma. The mean % recoveries in the case of spiked human plasma (n 4) was 92.59 3.11 and 88.35 2.55 using SDS and β-CD, respectively, while that in real human plasma (n 3) was 90.17 6.93 and 89.17 6.50 using SDS and β-CD, respectively. The application of the method was extended to the stability studies of VP HCl after exposureto ultraviolet radiation and upon oxidation with hydrogen peroxide.

Determination of Pantoprazole in Pharmaceutical Formulations and Human Plasma by Square‐Wave Voltammetry

2005 ◽  
Vol 38 (9) ◽  
pp. 1389-1404 ◽  
Author(s):  
Sacide Altınöz ◽  
Incilay Süslü
Keyword(s):  
Human Plasma ◽  
Square Wave Voltammetry ◽  
Pharmaceutical Formulations ◽  
Square Wave ◽  
Wave Voltammetry
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