Brain structural changes after multi‐strategic metamemory training in older adults with subjective memory complaints: A randomized controlled trial

AbstractObjectives: Subjective memory complaints (SMC) in older adults are associated with a decline in everyday functioning and an increased risk for future cognitive decline. This study examines the effect of a memory strategy training compared to a control memory training on memory functioning in daily life. Methods: This was a randomized controlled trial with baseline, post-treatment, and 6-month follow-up assessments conducted in 60 older adults (50–87 years) with SMC. Participants were randomly assigned to either seven sessions of memory strategy training or seven sessions of control memory training. Both interventions were given in small groups and included psycho-education. Primary outcome measure was memory functioning in daily life. Objective measures of memory performance and self-reported measures of strategy use were included as secondary outcome measures. Results: Participants in each intervention group reported an improvement in personal memory goals (p<.0005), up to 6 months after training. An interaction effect showed that participants following memory strategy training reported a larger improvement in personal memory goals (p=.002). Both intervention groups improved on two memory tests (p<.001 and p<.01). In the memory strategy training group, an increase in strategy use in daily life was the strongest predictor (p<.05) of improvement in subjective memory functioning. Conclusions: Older adults with subjective memory complaints benefit from memory strategy training, especially in their memory functioning in daily life. (JINS, 2018, 24, 1110–1120)

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Randomized controlled trial on the efficacy of a multilevel non-pharmacologic intervention in older adults with subjective memory decline: design and baseline findings of the E.Mu.N.I. study

Aging Clinical and Experimental Research ◽

10.1007/s40520-019-01403-3 ◽

2020 ◽

Vol 32 (5) ◽

pp. 817-826

Author(s):

Elena Rolandi ◽

Alessandra Dodich ◽

Samantha Galluzzi ◽

Clarissa Ferrari ◽

Sara Mandelli ◽

...

Keyword(s):

Older Adults ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Subjective Memory ◽

Memory Decline ◽

Pharmacologic Intervention ◽

Randomized Controlled

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Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: The AIBL Active trial

BMC Psychiatry ◽

10.1186/1471-244x-12-167 ◽

2012 ◽

Vol 12 (1) ◽

Cited By ~ 27

Author(s):

Elizabeth V Cyarto ◽

Nicola T Lautenschlager ◽

Patricia M Desmond ◽

David Ames ◽

Cassandra Szoeke ◽

...

Keyword(s):

Physical Activity ◽

Older Adults ◽

Randomized Controlled Trial ◽

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

Controlled Trial ◽

White Matter Changes ◽

Memory Complaints ◽

Randomized Controlled ◽

With Memory

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The Relieving Effects of BrainPower Advanced, a Dietary Supplement, in Older Adults with Subjective Memory Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2016/7898093 ◽

2016 ◽

Vol 2016 ◽

pp. 1-16 ◽

Cited By ~ 2

Author(s):

Jingfen Zhu ◽

Rong Shi ◽

Su Chen ◽

Lihua Dai ◽

Tian Shen ◽

...

Keyword(s):

Older Adults ◽

Dietary Supplement ◽

Controlled Trial ◽

Memory Function ◽

Memory Loss ◽

Subjective Memory Complaints ◽

Subjective Memory ◽

Double Blind ◽

Double Blind Placebo ◽

Memory Complaints

Subjective memory complaints (SMCs) are common in older adults that can often predict further cognitive impairment. No proven effective agents are available for SMCs. The effect of BrainPower Advanced, a dietary supplement consisting of herbal extracts, nutrients, and vitamins, was evaluated in 98 volunteers with SMCs, averaging 67 years of age (47–88), in a randomized, double-blind, placebo-controlled trial. Subjective hypomnesis/memory loss (SML) and attention/concentration deficits (SAD) were evaluated before and after 12-week supplementation of BrainPower Advanced capsules (n=47) or placebo (n=51), using a 5-point memory questionnaire (1 = no/slight, 5 = severe). Objective memory function was evaluated using 3 subtests of visual/audio memory, abstraction, and memory recall that gave a combined total score. The BrainPower Advanced group had more cases of severe SML (severity⩾3) (44/47) and severe SAD (43/47) than the placebo group (39/51 and 37/51, < 0.05, < 0.05, resp.) before the treatment. BrainPower Advanced intervention, however, improved a greater proportion of the severe SML (29.5%)(13/44) (P<0.01) and SAD (34.9%)(15/43)(P<0.01) than placebo (5.1% (2/39) and 13.5% (5/37), resp.). Thus, 3-month BrainPower Advanced supplementation appears to be beneficial to older adults with SMCs.

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