Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study

Alcohol consumption is a major risk factor for head and neck cancer (HNC), yet little data exist examining drinking patterns and HNC risk. In this population-based, retrospective cohort study, 11,737,467 subjects were recruited from the Korean National Health Insurance Service database. The risks of overall HNC and HNC subtypes according to average alcohol consumption, drinking frequency, and daily amount were examined using Cox proportional hazard models. Over the median follow-up of 6.4 years, 15,832 HNC cases were identified. HNC risk linearly increased with drinking frequency (p-trend < 0.01; adjusted hazard ratio [aHR] 1.55, 95% confidence interval [CI] 1.45–1.67 in subjects who drank 7 days/week). HNC risk also increased according to daily amount of alcohol consumption (p-trend < 0.01), but plateaued from 5–7 units/occasion (aHR 1.25, 95% CI 1.19–1.31) to >14 units/occasion (aHR 1.26, 95% CI 1.13–1.40). When stratified by average alcohol consumption, drinking frequency, but not daily amount, showed a linear relationship with HNC risk in moderate and heavy drinkers. When comparing the HNC subtypes, similar tendencies were observed in cancers of the oral cavity, pharynx, and larynx, but not in the salivary gland. In conclusion, drinking frequency is a stronger risk factor for HNC, especially for cancer of the oral cavity, pharynx, and larynx, than the daily amount of alcohol consumption.

Sociodemographic Profiles And Psychiatric Comorbidities Among Patients With Alcohol Dependence In Western Nepal

Introduction: Alcohol is a potent drug that causes acute and chronic changes in almost all neurochemical systems and heavy drinking can produce serious temporary psychological symptoms including depression, anxiety and psychoses. Alcoholism is clinically heterogenous disorder with variable age of onset, drinking patterns, severity and comorbidity with other mental disorders. There is a gender difference in many aspect of alcohol use. The aim of the study was to study the sociodemographic profile, severity, gender difference and psychiatric comorbidities in patient with alcohol dependence syndrome in Nepalese population. Material And Method: This is a hospital based study done in patients coming to Nepalgunj Medical College, Kohalpur over a period of one year from June 2019 to May 2020 on consecutive serial basis. Diagnosis of alcohol dependence was made based on International Classification of Disease-10 (ICD-10) criteria. Semi structured proforma and Severity of Alcohol Dependence Questionnaire (SADQ) was applied in those patients and recorded accordingly. The data was analyzed using SPSS. Results: Out of 40 patients studied (N-40), 37 (92.5 %) were male and 3 (7.5 %) were female. Alcohol dependence is most common in the age bracket of 30-39 (43.1%) followed by 40-49 (33.4 %) with mean age of 40.3 years and the mean age of duration of alcohol use being 13.45 years. The mean amount of alcohol consumed per day is 92.25 grams. The SADQ scores, age of first alcohol use, duration of alcohol use in years and daily amount of alcohol use in grams is significantly different between male and female. Similarly there is severe alcohol dependence in 75 % while moderate level in 25 % of study population. Regarding psychiatric comorbidities, 90 % have comorbid other substance use disorder followed by anxiety disorders in 37.5 %, personality disorders in 35 %, mood disorders in 32.5 %, deliberate self harm in 30 % and psychotic disorders in 12.5 %. Conclusion: Alcohol dependence is most commonly found in young and adults of various age group. Age of first alcohol use, duration of alcohol use in years and daily amount of alcohol use in grams is significantly different between male and female. Alcohol dependence is comorbid with multiple psychiatric entities.

PSIX-12 “Lamarin Saldonum” for the raising of milk production of cows

The aim of the research was to establish the effectiveness of the use of the feed additive “Lamarin Saldonum.” The feed additive contains Japanese kelp, milk thistle, to increase the milk productivity during the milking period. The studies were conducted on 40 cows of the black-and-white Holstein breed at the age of 2–4 lactation and the amount of milk for the last lactation not less than 7,500 kg. The cows were divided into 4 groups (GE1, GE2, GE3, GC) of 10 heads in each. Cows GE1, GE2, GE3 received 30 days before calving daily feed additive in doses of 0.1, 0.2, 0.3 g/kg, respectively, for 60 days. In the GC animals didn’t receive the feed additive (control group). Control milking was performed every 10 days. Using of feed additive in the ration increased milk productivity. In the 1st month of lactation, the average daily amount of milk in GC was 24.00±0.93 kg, which is 7.4%, 19.6% (P &lt; 0.01), 7.4% less than in GE1, GE2 and GE3, respectively. In the 2nd month, the highest average daily amount of milk in GE2 and GE3, which is 13.4% (P &lt; 0.01) and 4.6% more than the GC, respectively. In the 3rd month, the average daily amount of milk in GE1, GE2, and GE3 was 30.22±2.44 kg, 39.57±2.68 kg, 35.11±2.59 kg, respectively, which is 6.8%, 39.9% (P &lt; 0.01), 24.1% more than in GC. The mass fraction of fat in milk in animals GE1, GE2, GE3 was 0.2–0.92%(P &lt; 0.01) higher than in GC. In the second month of lactation, the mass fraction of protein in GE2 was higher by 0.24% (P &lt; 0.01), in GE3–by 0.14 (P &lt; 0.05) relative to GC. At the 3rd month of lactation, the protein content in milk was 0.29% higher in GE2 (P &lt; 0.001) and GE3-by 0.21% (P &lt; 0.001) than in GC.

Betel Nut Chewing Was Associated with Obstructive Lung Disease in a Large Taiwanese Population Study

The prevalence of betel nut chewing in Taiwan is high at approximately 7%, however, few studies have evaluated the relationship between betel nut chewing and lung disease. Therefore, the aim of this study was to investigate associations between betel nut chewing and lung function in 80,877 participants in the Taiwan Biobank (TWB). We further investigated correlations between betel nut chewing characteristics such as years of use, frequency, daily amount, and accumulative dose, with obstructive lung disease. We used data from the TWB. Lung function was assessed using spirometry measurements of forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). The participants were classified into normal lung function and obstructive lung function (FEV1/FVC < 70%) groups. The participants were asked questions about betel nut chewing, including years of use, frequency, and daily amount. After multivariable analysis, betel nut chewing (odds ratio [OR] = 1.159; p < 0.001) was significantly associated with FEV1/FVC < 70% in all participants (n = 80,877). Further, in the participants who chewed betel nut (n = 5135), a long duration of betel nut chewing (per 1 year; OR = 1.008; p = 0.012), betel nut use every day (vs. 1–3 days/month; OR = 1.793; p = 0.036), 10–20 quids a day (vs. <10 quids; OR = 1.404; p = 0.019), 21–30 quids a day (vs. <10 quids; OR = 1.662; p = 0.010), ≥31 quids a day (vs. <10 quids; OR = 1.717; p = 0.003), and high cumulative dose (per 1 year × frequency × daily score; OR = 1.001; p = 0.002) were significantly associated with FEV1/FVC < 70%. In this large population-based cohort study, chewing betel nut was associated with obstructive lung disease. Furthermore, a long duration of betel nut chewing, more frequent use, higher daily amount, and high cumulative dose were associated with obstructive lung disease. This suggests that preventing betel nut chewing should be considered to reduce obstructive lung disease in Taiwan.

The Influence of Front-of-Package Nutrition Labeling on Consumer Behavior and Product Reformulation

Countries worldwide have implemented mandatory or voluntary front-of-package nutrition labeling systems. We provide a narrative review of ( a) real-world evaluations of front-of-package nutrition labels that analyze objective sales data and ( b) studies that objectively assess product reformulation in response to a front-of-package nutrition label implementation. We argue that there is sufficient scientific evidence to recommend that governments implement mandatory front-of-package nutrition labeling systems to improve population health. We also present a conceptual framework to describe front-of-package label influence and provide recommendations for the optimal label design, emphasizing that labeling systems should be highly visible and salient, be simple and easy to understand, leverage automatic associations, and integrate informational and emotional messaging. The existing research suggests that Guideline Daily Amount labels should be avoided and that the Health Star Rating and Nutri-Score systems are promising but that systems with warning labels like the one in Chile are likely to produce the largest public health benefits. Expected final online publication date for the Annual Review of Nutrition, Volume 41 is September 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

A tüdő immunfiziológiája – útjelzők a terra incognita felé

Összefoglaló. A tüdő a benne lévő légutak és a légzőhám felületének kiterjedtsége, valamint a folyamatos napi gázcsere mennyisége miatt az emlősszervezetnek a környezeti antigének számára legnagyobb mértékben kitett közvetlen behatolási kapuja. A különböző antigénekkel szemben számos fizikai-mechanikai tisztulási folyamat, valamint helyi és szisztémás immunológiai védelmi mechanizmus együttesen biztosítja a légutak átjárhatóságát és a megfelelő gázcseréhez a légzőhám és a tüdő interstitialis összetevőinek szöveti integritását. A tüdő – veleszületett és adaptív immunológiai – védelmét ellátó molekuláris és sejtes résztvevőkre, ezáltal a légutak alapvető életfontosságú működésének biztosítására vonatkozó ismereteink az utóbbi időben számos új megfigyeléssel bővültek, melyek felvetik a tüdő immunológiai szerveződésének egyedi szerkezeti és funkcionális specializációját. A jelen összefoglaló célja ezeknek az új eredményeknek a bemutatása, ezen keresztül a tüdőben zajló sokrétű immunológiai folyamatok főbb jellemzőinek és a bennük részt vevő sejtes és molekuláris összetevőknek az áttekintése. Ezek részletesebb megismerése elősegítheti a légúti (köztük a SARS-CoV-2 általi) fertőzések után fellépő, helyi és szisztémás immunpatológiai események pontosabb megértését és a lehetséges terápiás eljárások kritikai értelmezését. Orv Hetil. 2021; 162(29): 1147–1155. Summary. Due to the size of the surface area of airways and respiratory epithelium combined with the daily amount of continuous gas exchange, in mammalians the lung represents the most exposed organ serving as immediate entry port for airborne antigens. Together with several physicochemical clearance processes, both local and systemic immunological defense mechanisms ensure the passage of airways and the tissue integrity of respiratory epithelium and pulmonary interstitium necessary for the maintenance of gas exchange. Several recent observations concerning the molecular and cellular constituents of the pulmonary immunological defense have substantially broadened our knowledge of the maintenance of the vital functionality of airways, raising the unique specialization of the organization of pulmonary immune compartment. The purpose of the present review is to highlight the main findings on the complexity of pulmonary immunity, including the overview of the main characteristics of its cellular and molecular participants. Unrevealing these mechanisms may promote our understanding the local and systemic immunopathological processes occurring after airway infections (including SARS-CoV-2) and the critical assessment of potential therapeutic interventions. Orv Hetil. 2021; 162(29): 1147–1155.

Selos nutricionais frontais em embalagem de alimentos: um estudo comparativo da sua detectabilidade

Existem diferentes riscos decorrentes da ingestão dos alimentos ultraprocessados, ocasionando um debate sobre o impacto da sua inclusão nas dietas brasileiras. Nesse sentido, órgãos ligados à saúde pública têm buscado estabelecer novas normas de rotulagem, a fim de promover um maior acesso à informação nutricional e auxiliar o consumidor a tomar escolhas alimentares conscientes. Sabendo que já existem vários modelos de selos nutricionais frontais em uso ao redor do mundo e que a sua eficiência depende da capacidade do usuário em detectar, ler e compreender as informações, o trabalho aqui apresentado investigou a detectabilidade dos três modelos mais comuns no mercado internacional, sendo eles o GDA (guideline daily amount), o semáforo nutricional e o octógono chileno. Levando em consideração alguns estudos que apontam diferenças no processamento de informações por homens e mulheres, esta pesquisa buscou também investigar se a capacidade de detecção dos selos nutricionais frontais pode variar entre os sexos. Em ambiente controlado e utilizando um óculos para rastreamento ocular, 45 homens e 45 mulheres com idade entre 18 e 60 anos testaram os modelos de selo em uma embalagem fictícia de suco de laranja para depois responderem a um breve questionário pós-teste. Baseados em dados quantitativos coletados com a ferramenta para eye-tracking, o estudo apresenta uma análise de covariância (ANCOVA) de duas vias dos resultados encontrados concluindo que não houve diferenças no tempo para primeira entrada, na frequência relativa de visitas ou no tempo de permanência. Os três modelos de selos foram detectados da mesma maneira pelos participantes da amostra e também não foram observadas diferenças entre a detecção de homens e mulheres.

Research of the content of phenolic compounds, flavonoids and iodine in chocolate using non-traditional raw materials

A study to determine the total content of phenolic compounds, flavonoids and mass fraction of iodine in chocolate using non-traditional raw materials has been conducted. The object of the study was chocolate products, containing stevioside, erythrol, germinated soy flour, enriched with iodine. Carrying out this set of studies is important because it will determine the content of phenolic compounds, flavonoids and iodine in the developed chocolate. Based on the obtained patterns, it is possible to determine the percentage of satisfaction of the recommended daily requirement and to set the recommended amount of consumption of the developed product per day. As a result of research, it has been found, that the total content of phenolic compounds in the control type of chocolate per 198 mg of GA / 100 g of the initial raw material is less compared to the sample of chocolate, where non-traditional raw materials were used. The results of the study correlate with the results of determining the total content of flavonoids. The developed types of chocolate exceed control samples by 229 mg of C / 100 g of the initial raw material. That satisfies 88.6% of the recommended daily amount. It has been found, that the developed type of chocolate is a carrier of iodine in the amount of 63 μg / 100 g. In the control sample of chocolate there were found only traces of mass fraction of iodine. It has been determined, that the use of germinated soy flour, enriched with iodine in the amount of 10%, due to the reduction of cocoa mass satisfies 42% of the recommended daily amount of iodine for a woman aged 30… 40 years of average labor intensity. The obtained results are useful and important because they will allow to develop recommendations for the consumption of chocolate using non-traditional raw materials. What will affect the solution of an important social problem - maintaining high efficiency, confrontation with environmental factors under the pandemic due to the influx of test substances