The effects of cognitive behavioral therapy on resting-state functional brain network in drug-naive patients with obsessive-compulsive disorder

Cognitive behavioral therapy (CBT) is an effective treatment for many with obsessive–compulsive disorder (OCD). However, response varies considerably among individuals. Attaining a means to predict an individual’s potential response would permit clinicians to more prudently allocate resources for this often stressful and time-consuming treatment. We collected resting-state functional magnetic resonance imaging from adults with OCD before and after 4 weeks of intensive daily CBT. We leveraged machine learning with cross-validation to assess the power of functional connectivity (FC) patterns to predict individual posttreatment OCD symptom severity. Pretreatment FC patterns within the default mode network and visual network significantly predicted posttreatment OCD severity, explaining up to 67% of the variance. These networks were stronger predictors than pretreatment clinical scores. Results have clinical implications for developing personalized medicine approaches to identifying individual OCD patients who will maximally benefit from intensive CBT.

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Resting-state connectivity of the amygdala predicts response to cognitive behavioral therapy in obsessive compulsive disorder

Biological Psychology ◽

10.1016/j.biopsycho.2015.09.004 ◽

2015 ◽

Vol 111 ◽

pp. 100-109 ◽

Cited By ~ 32

Author(s):

Martin Göttlich ◽

Ulrike M. Krämer ◽

Andreas Kordon ◽

Fritz Hohagen ◽

Bartosz Zurowski

Keyword(s):

Cognitive Behavioral Therapy ◽

Obsessive Compulsive Disorder ◽

Resting State ◽

Behavioral Therapy ◽

Cognitive Behavioral ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Resting State Connectivity

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The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description

Brazilian Journal of Psychiatry ◽

10.1590/s1516-44462009000400011 ◽

2009 ◽

Vol 31 (4) ◽

pp. 349-353 ◽

Cited By ~ 15

Author(s):

Marcelo Queiroz Hoexter ◽

Roseli Gedanke Shavitt ◽

Carina Chaubet D'Alcante ◽

Janaina Philippi Cecconi ◽

Juliana Belo Diniz ◽

...

Keyword(s):

Clinical Trial ◽

Magnetic Resonance ◽

Cognitive Behavioral Therapy ◽

Obsessive Compulsive Disorder ◽

Behavioral Therapy ◽

Magnetic Resonance Images ◽

Obsessive Compulsive ◽

Compulsive Disorder ◽

Drug Naïve ◽

Neuropsychological Evaluations

OBJECTIVE: To describe a protocol that was based on an integrative neurobiological model of scientific investigation to better understand the pathophysiology of obsessive-compulsive disorder and to present the clinical and demographic characteristics of the sample. METHOD: A standardized research protocol that combines different methods of investigation (genetics, neuropsychology, morphometric magnetic resonance imaging and molecular neuroimaging of the dopamine transporter) obtained before and after treatment of drug-naïve adult obsessive-compulsive disorder patients submitted to a sequentially allocated 12-week clinical trial with a selective serotonin reuptake inhibitor (fluoxetine) and group cognitive-behavioral therapy. RESULTS: Fifty-two treatment-naïve obsessive-compulsive disorder patients entered the clinical trial (27 received fluoxetine and 25 received group cognitive-behavioral therapy). At baseline, 47 blood samples for genetic studies, 50 neuropsychological evaluations, 50 morphometrical magnetic resonance images and 48 TRODAT-1 single-photon emission computed tomography (SPECT) exams were obtained. After 12 weeks, 38 patients completed the protocol (fluoxetine = 20 and GCBT = 18). Thirty-eight neuropsychological evaluations, 31 morphometrical magnetic resonance images and 34 TRODAT-1 SPECT exams were obtained post-treatment. Forty-one healthy controls matched for age, gender, socioeconomic status, level of education and laterality were submitted to the same research procedures at baseline. CONCLUSION: The comprehensive treatment response protocol applied in this project allowing integration on genetic, neuropsychological, morphometrical and molecular imaging of the dopamine transporter data in drug-naïve patients has the potential to generate important original information on the neurobiology of obsessive-compulsive disorder, and at the same time be clinically meaningful.

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