scholarly journals Better effect of intrapleural perfusion with hyperthermic chemotherapy by video‐assisted thoracoscopic surgery for malignant pleural effusion treatment compared to normothermic chemoperfusion of the pleural cavity

2021 ◽  
Author(s):  
Yejun Cao ◽  
Qiying Zhang ◽  
Zhiyuan Huang ◽  
Zhengjun Chai ◽  
Jie Liu ◽  
...  
2012 ◽  
Vol 125 (3) ◽  
pp. 646-648 ◽  
Author(s):  
Jenny M. Whitworth ◽  
Kellie E. Schneider ◽  
Janelle M. Fauci ◽  
Ayesha S. Bryant ◽  
Robert J. Cerfolio ◽  
...  

ASVIDE ◽  
2016 ◽  
Vol 3 ◽  
pp. 503-503
Author(s):  
Marcin Zieliński ◽  
Mariusz Rybak ◽  
Katarzyna Solarczyk-Bombik ◽  
Michal Wilkoj ◽  
Wojciech Czajkowski ◽  
...  

2018 ◽  
Vol 106 (2) ◽  
pp. 361-367 ◽  
Author(s):  
Christine M. McDonald ◽  
Camille Pierre ◽  
Marc de Perrot ◽  
Gail Darling ◽  
Marcelo Cypel ◽  
...  

2021 ◽  
Author(s):  
Xinxin Wang ◽  
Min Kong ◽  
Jiang Jin ◽  
Yulian Lin ◽  
Limin Jia ◽  
...  

Abstract Background: Patients with malignant pleural effusion (MPE) have a poor prognosis. Most patients are treated with tube thoracostomy and sclerotherapy but with a not satisfactory control rate of pleural effusion. This study aims to report the effect of intrapleural hyperthermic perfusion for MPE which is a standard practice at our center.Methods: This is a retrospective study of consecutive patients with MPE treated with hyperthermic perfusion from one single Institute. The procedure was done by perfusing the pleural cavity under video-assisted thoracoscope with 43.0°C distilled water using a standard extracorporeal circuit for 60 minutes. The efficacy of treatment was classified as follows: 1. complete response (CR; no re-accumulation of pleural effusion after IPH for at least four weeks); 2. partial response (PR; pleural effusion was reduced by 50% and this situation was sustained for four weeks; 3. no consequence (NC; pleural effusion was not reduced.Results: From January 2014 through December 2018, a total of 31 patients with MPE were treated using this technique. There were no serious reportable clinical complications associated with the procedures. The response rate was 100%, with 67.7% of PR and 32.3% of CR. The survival time ranged from 2 to 46 months, with a median survival of 12 months. The survival time of the patients received TKI treatment after IHP ranged from 13 to 45 months, with a median survival of 28 months. Multivariable analysis showed that TKI treatment (P=0.013) and male gender (P=0.004) were independent prognosis factors.Conclusions: Intrapleural hyperthermic perfusion is a feasible and safe strategy for patients with malignant pleural effusion.


2020 ◽  
Vol 7 (11) ◽  
pp. 3880
Author(s):  
Mayank Badkur ◽  
Suruthi Baskaran ◽  
Satya Prakash ◽  
Lalit Kishore ◽  
Mahendra Lodha ◽  
...  

Thoracic trauma is a significant cause of morbidity and mortality, if not treated promptly. 80% to 85% of chest injuries can be treated with chest tube insertion alone. However, in about four to 20% of population, there is incomplete clearance of hemothorax following tube insertion and can lead to a condition called retained hemothorax. The purpose of this review is to establish the role and effectiveness of Video assisted thoracoscopic surgery (VATS) in successful evacuation of retained hemothorax following blunt thoracic trauma. Relevant articles from databases like Pubmed, Google scholar, Medline and Cochrane library were included. A retained hemothorax is defined as the persistence of residual clots in the pleural cavity, which is radiologically evident, 72 hours following initial tube thoracostomy. The various options to manage this condition include observation, insertion of second thoracostomy tube, intrapleural fibrinolytic, VATS or thoracotomy. Based on review of existing studies, VATS evacuation was found to have shorter hospital stay, lesser costs and shorter duration of tube drainage. There was also lesser rate of conversion to thoracotomy as compared to other methods and fewer complications like fibrothorax and empyema. In hemodynamically unstable patients, which is a contraindication to VATS, use of intrapleural fibrinolytics like streptokinase may be considered as an alternative option to provide clearance of the retained hemothorax. Retained hemothorax, when encountered following thoracic trauma, can be effectively managed by VATS. The decision to use VATS for hemothorax evacuation should be made promptly for maximum results, especially within three to seven days following trauma.


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