scholarly journals Acquired thrombotic thrombocytopenic Purpura diagnosed during first trimester of pregnancy with excellent outcome after plasma exchange and rituximab, a case report

2021 ◽  
Vol 9 (3) ◽  
pp. 1304-1306
Author(s):  
Javier Arzuaga‐Mendez ◽  
Maite Moreno ◽  
Juan J. Mateos‐Mazón ◽  
Miriam Vara ◽  
Marta Dueñas ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
First Trimester ◽  
Thrombocytopenic Purpura ◽  
Excellent Outcome ◽  
First Trimester Of Pregnancy

scholarly journals Thrombotic thrombocytopenic purpura in the first trimester of pregnancy

2013 ◽  
Vol 7 (1) ◽  
pp. 79 ◽  
Author(s):  
Pooja Sikka ◽  
Seema Chopra ◽  
Neelam Aggarwal ◽  
Vanita Suri ◽  
Abi Chandrasekaran
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
First Trimester ◽  
Thrombocytopenic Purpura ◽  
First Trimester Of Pregnancy

scholarly journals Treating thrombotic thrombocytopenic purpura without plasma exchange during the COVID-19 pandemic. A case report and a brief literature review

2021 ◽  
pp. 103107
Author(s):  
César David Galindo-Calvillo ◽  
Carlos Saúl Rodríguez-Roque ◽  
Andrés Gómez-De León ◽  
Luz Tarín-Arzaga ◽  
David Gómez-Almaguer
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura

scholarly journals Successful treatment of plasma exchange-refractory thrombotic thrombocytopenic purpura with rituximab: A case report

2020 ◽  
Vol 8 (12) ◽  
pp. 2617-2622
Author(s):  
Jian Chen ◽  
Jing-Xia Jin ◽  
Xiao-Fei Xu ◽  
Xuan-Xuan Zhang ◽  
Xing-Nong Ye ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Successful Treatment ◽  
Thrombocytopenic Purpura

Pregnancy-associated Thrombotic Thrombocytopenic Purpura: A Single Institution's Experience

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 4675-4675
Author(s):  
Jordana Boro ◽  
Katerina Pavenski ◽  
John J. Freedman ◽  
Marie B. Garvey ◽  
Lisa K Hicks
Keyword(s):  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Conflicts Of Interest ◽  
Post Partum ◽  
First Trimester ◽  
Fresh Frozen Plasma ◽  
Blood Film ◽  
Intrauterine Death ◽  
Thrombocytopenic Purpura ◽  
Fresh Frozen

Abstract Abstract 4675 Thrombotic thrombocytopenic purpura (TTP) is a rare, life-threatening form of microangiopathic hemolysis that can be associated with pregnancy. Although the association between TTP and pregnancy is well recognized, the presentation, natural history, and ideal treatment of TTP in this population remain poorly understood. St. Michael's Hospital is a regional referral centre for TTP in Ontario, Canada. We conducted a retrospective review of all cases of TTP referred to our pheresis unit between July 1993 and May 2010. Ninety-four cases were identified, of these, ten patients were pregnant or up to one week post-partum at the time of TTP diagnosis. Median age at presentation was 34 (29-36). Only one patient had been previously diagnosed with TTP and then developed a TTP relapse while pregnant. At presentation, all patients had thrombocytopenia (platelets: < 3 to 124 × 106/ml), anemia (hemoglobin: 60 to 99 mg/L), elevated LDH (1.3 to 12.5 × ULN), and fragmentation on blood film. ADAMTS13 was assessed in six of ten patients. It was normal in four patients, and deficient in two patients. Seven patients had neurological symptoms at presentation, one of whom suffered permanent right sided paralysis. Six patients had depressed glomerular filtration ratio (GFR) at presentation, four of these six recovered normal GFR. Hypertension was present in only one patient, and no patients had abnormal coagulation parameters at presentation. ALT was normal in six patients, mildly elevated in two patients, and unavailable in two patients. There were no patient deaths in this series. Patients were treated with a median of 17 plasma exchanges (range: 9 to 55) using either fresh frozen plasma or cryosupernatant. Eight patients achieved complete remission with plasma exchange. Two patients had refractory disease which ultimately responded to splenectomy and rituximab respectively. There were two fetal deaths, one a first trimester miscarriage, and the second an intrauterine death in the second trimester. In conclusion, in our series of pregnancy associated-TTP, there were no maternal deaths and most women responded to a short course of plasma exchange. ADAMTS13 deficiency was uncommon in our series. Nonetheless, in our series, TTP was not difficult to distinguish from preeclampsia and/or disseminated intravascular coagulation using routine laboratory parameters. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Relapse of Immune Thrombotic Thrombocytopenic Purpura Following Vaccination with COVID19 mRNA Vaccine

TH Open ◽  
2021 ◽  
Vol 05 (03) ◽  
pp. e335-e337
Author(s):  
Katerina Pavenski
Keyword(s):  
Case Report ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Previous History ◽  
Therapeutic Plasma Exchange ◽  
Patient Treatment ◽  
High Dose ◽  
Thrombocytopenic Purpura ◽  
History Of

AbstractAn 84 year old male with a previous history of immune thrombotic thrombocytopenic purpura (iTTP) received the first dose of COVID19 mRNA vaccine (Pfizer-Biontech). Seven days later he was diagnosed with iTTP relapse. He received in-patient treatment with therapeutic plasma exchange, high dose steroids and rituximab and subsequently recovered. This case report highlights the need to monitor patients with iTTP following vaccination.

Relapsed/refractory thrombotic thrombocytopenic purpura treated with N-acetylcysteine: a case report

2018 ◽  
Vol 63 (4) ◽  
pp. 122-124
Author(s):  
Sinan Demircioğlu ◽  
Ömer Ekinci ◽  
Ali Doğan ◽  
Cengiz Demir
Keyword(s):  
Case Report ◽  
Renal Impairment ◽  
Plasma Exchange ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Treatment Options ◽  
Rare Condition ◽  
High Dose ◽  
Thrombocytopenic Purpura ◽  
Loss Of Response ◽  
Refractory Case

Thrombotic thrombocytopenic purpura is a rare condition that presents with microangiopathic haemolytic anaemia, thrombocytopaenia, fever, renal impairment and neurological symptoms. Plasma exchange is a lifesaving treatment for this condition. However, some cases may be non-responsive to plasma exchange, or loss of response may occur. Treatment options for refractory cases include high-dose corticosteroids, rituximab, vincristine, cyclophosphamide, splenectomy, bortezomib and N-acetylcysteine. We present a refractory case of thrombotic thrombocytopenic purpura responding to the last of these therapies.

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