Screening of minimalist noncanonical sites in duplex DNA and RNA reveals context and motif‐selective binding by fluorogenic base probes

2021 ◽  
Author(s):  
Yufeng Liang ◽  
Shiqin Miao ◽  
Jie Mao ◽  
Shekaraiah Devari ◽  
Maricarmen Gonzalez ◽  
...  
Keyword(s):  
Duplex Dna ◽  
Selective Binding ◽  
Dna And Rna

scholarly journals Effects of site-specific substitution of 5-fluorouridine on the stabilities of duplex DNA and RNA

1995 ◽  
Vol 23 (19) ◽  
pp. 3916-3921 ◽  
Author(s):  
Parag V. Sahasrabudhe ◽  
Richard T. Pon ◽  
William H. Gmeiner
Keyword(s):  
Duplex Dna ◽  
Site Specific ◽  
Dna And Rna

Control over the Localization of Positive Charge in DNA:  The Effect on Duplex DNA and RNA Stability

1998 ◽  
Vol 120 (46) ◽  
pp. 12165-12166 ◽  
Author(s):  
Lauren E. Heystek ◽  
Hui-qiang Zhou ◽  
Prasad Dande ◽  
Barry Gold
Keyword(s):  
Positive Charge ◽  
Rna Stability ◽  
Duplex Dna ◽  
Dna And Rna

Use of shaped pulses for semi-selective excitation of imino1H resonances in duplex DNA and RNA

1995 ◽  
Vol 33 (6) ◽  
pp. 449-452 ◽  
Author(s):  
William H. Gmeiner ◽  
Parag Sahasrabudhe ◽  
Richard T. Pon
Keyword(s):  
Selective Excitation ◽  
Duplex Dna ◽  
Dna And Rna

Stabilization of duplex DNA and RNA by dangling ends studied by free energy simulations

Biopolymers ◽  
2014 ◽  
Vol 101 (4) ◽  
pp. 418-427 ◽  
Author(s):  
Mahmut Kara ◽  
Martin Zacharias
Keyword(s):  
Free Energy ◽  
Duplex Dna ◽  
Dna And Rna ◽  
Energy Simulations

High-resolution nucleic acid sequence mapping via in situ hybridization at the Electron Microscope level

1995 ◽  
Vol 53 ◽  
pp. 752-753
Author(s):  
B.A. Hamkalo ◽  
S. Narayanswami ◽  
A.P. Kausch
Keyword(s):  
Nucleic Acid ◽  
Interphase Nucleus ◽  
Genome Mapping ◽  
Precise Location ◽  
Electron Microscope Level ◽  
Rna Sequences ◽  
Fundamental Interest ◽  
Whole Cells ◽  
Dna And Rna

The availability of nonradioactive methods to label nucleic acids an the resultant rapid and greater sensitivity of detection has catapulted the technique of in situ hybridization to become the method of choice to locate of specific DNA and RNA sequences on chromosomes and in whole cells in cytological preparations in many areas of biology. It is being applied to problems of fundamental interest to basic cell and molecular biologists such as the organization of the interphase nucleus in the context of putative functional domains; it is making major contributions to genome mapping efforts; and it is being applied to the analysis of clinical specimens. Although fluorescence detection of nucleic acid hybrids is routinely used, certain questions require greater resolution. For example, very closely linked sequences may not be separable using fluorescence; the precise location of sequences with respect to chromosome structures may be below the resolution of light microscopy(LM); and the relative positions of sequences on very small chromosomes may not be feasible.

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