ChemInform Abstract: A NOVEL SYNTHETIC ROUTE TO CYCLOPROPANE DERIVATIVES FROM OLEFINS

Synthetic route for the synthesis of tetrasubstituted furan fatty acids; including experimental details, characterisation, and spectral data of all intermediates.

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Palladium-Catalyzed Asymmetric Annulation Between Aryl Iodides and Racemic Epoxides Using a Chiral Norbornene Cocatalyst

10.26434/chemrxiv.6635312 ◽

2018 ◽

Author(s):

Guangbin Dong ◽

Renhe Li

Keyword(s):

Isopropyl Ester ◽

Synthetic Route ◽

Initial Development ◽

Aryl Iodides ◽

Palladium Catalyzed

Herein, we describe our initial development of an asymmetric Pd-catalyzed annulation between aryl iodides and racemic epoxides for synthesis of 2,3-dihydrobenzofurans using a chiral norbornene cocatalyst. A series of enantiopure ester-, amide- and imide-substituted norbornenes have been prepared with a reliable synthetic route. Promising enantioselectivity (42-45% ee) has been observed using the isopropyl ester-substituted norbornene (N1*) and the amide-substituted norbornene (N7*).

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Computational Analysis of Some Aspects of a Synthetic Route to Ammonium Dinitramide

10.21236/ada274648 ◽

1993 ◽

Author(s):

Tore Brinck ◽

Peter Politzer

Keyword(s):

Computational Analysis ◽

Synthetic Route ◽

Ammonium Dinitramide

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Synthesis and Biological Properties of some New Lead Sulphonamide and Carboxamide Scaffolds Bearing Coumarin Moiety (Mini Review)

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557520666200730154458 ◽

2020 ◽

Vol 20 ◽

Author(s):

Cosmas Chinweike Eze ◽

Mercy Amarachukwu Ezeokonkwo ◽

Benjamin Ebere Ezema ◽

Abraham Efeturi Onoabedje ◽

David Izuchukwu Ugwu

Keyword(s):

Biological Properties ◽

Therapeutic Agents ◽

Amide Group ◽

Pharmacological Properties ◽

Important Class ◽

Synthetic Route ◽

Therapeutic Activities

: Coumarin, sulphonamide and amide scaffolds exhibit diverse pharmacological features and constitute an important class of therapeutic agents. In this review, we have discussed the synthesis, biological properties, and SAR of coumarins containing sulphonamide or amide group in the last seven years. Many reviews on the therapeutic activities of coumarins, sulphonamides, and amides have been published, hence the authors focused on coumarin-linked sulphonamide or amide scaffolds. The review provides information on the synthetic route to new coumarins containing sulphonamide or amide groups with improved pharmacological properties.

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