ChemInform Abstract: THE CHROMOUS CHLORIDE PROMOTED ADDITION OF N-HALOAMIDES TO OLEFINS. V. THE ADDITION OF N-CHLOROAMIDES TO ENOL ETHERS- SYNTHESIS OF ACYLOXY AND ACYL DERIVATIVES OF α-AMINO ACETALS AND KETALS (ALDEHYDES AND KETONES) AND OF 2-AMINO SUGAR

1978 ◽  
Vol 9 (21) ◽  
Author(s):  
H. DRIGUEZ ◽  
J.-P. VERMES ◽  
J. LESSARD
Keyword(s):  
Amino Sugar ◽  
Enol Ethers ◽  
Aldehydes And Ketones ◽  
Derivatives Of ◽  
Chromous Chloride ◽  
Acyl Derivatives

The chromous chloride promoted addition of N-haloamides to olefins. V. The addition of N-chloroamides to enol ethers: synthesis of acyloxy and acyl derivatives of α-amino acetals and ketals (aldehydes and ketones) and of 2-amino sugars

1978 ◽  
Vol 56 (1) ◽  
pp. 119-130 ◽  
Author(s):  
Hugues Driguez ◽  
Jean-Paul Vermes ◽  
Jean Lessard
Keyword(s):  
Addition Product ◽  
Amino Sugars ◽  
Enol Ethers ◽  
Aldehydes And Ketones ◽  
Work Up ◽  
Derivatives Of ◽  
Chromous Chloride ◽  
Acyl Derivatives

The chromous chloride promoted addition of N-chlorocarbamates and N-chlorocarboxamides to 1-methoxycyclohexene, ethoxyethylene, dihydropyran, and (1-methoxyethylidene)-cyclohexane gave, in 60 to 85% yields, either α-acyloxy- or α-acylamino ketals and acetals, or the corresponding ketones and aldehydes depending on the work-up conditions. The regio-specificity of the addition was higher with the first two enol ethers (≥97%) than with the latter two (≥85%). N-Chlorourethane was added to 17-methoxymethylenandrost-4-en-3-one (19) and the sole addition product isolated was the 17α-chloro-20-ethoxycarbonylamino derivative 20 in 75% yield. Additions to triacetyl-D-glucal and 3-O-acetyl-4,6-O-benzylidene-D-glucal followed by solvolysis under Koenigs–Knorr conditions led predominantly to 2-amino-gluco-pyranosides in 30 to 65% yields, whereas additions to 3-O-acetyl-4,6-O-benzylidene-D-allal gave 2-amino altropyranosides in 40 to 56% yields.

scholarly journals Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1608
Author(s):  
Stephen Lo ◽  
Euphemia Leung ◽  
Bruno Fedrizzi ◽  
David Barker
Keyword(s):  
Antiproliferative Activity ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Breast Cancer Cell Lines ◽  
Scavenging Activity ◽  
Plant Materials ◽  
Wide Range ◽  
Derivatives Of ◽  
Acyl Derivatives

Quercetin is a flavonoid that is found in many plant materials, including commonly eaten fruits and vegetables. The compound is well known for its wide range of biological activities. In this study, 5-O-acyl derivatives of quercetin were synthesised and assessed for their antiproliferative activity against the HCT116 colon cancer and MDA-MB-231 breast cancer cell lines; and their radical scavenging activity against the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical species. Four derivatives were found to have improved the antiproliferative activity compared to quercetin whilst retaining radical scavenging activity.

ChemInform Abstract: O-ACYL DERIVATIVES OF 2-PYRIDINALDOXIME

1978 ◽  
Vol 9 (52) ◽  
Author(s):  
P. YA. ROMANOVSKII ◽  
A. YU. KRIKIS ◽  
G. I. CHIPENS
Keyword(s):  
Derivatives Of ◽  
Acyl Derivatives
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