ChemInform Abstract: SYN ELIMINATION OF ALKYL SELENOXIDES. SIDE REACTIONS INVOLVING SELENENIC ACIDS. STRUCTURAL AND SOLVENT EFFECTS OF RATES

1978 ◽  
Vol 9 (37) ◽  
Author(s):  
H. J. REICH ◽  
S. WOLLOWITZ ◽  
J. E. TREND ◽  
F. CHOW ◽  
D. F. WENDELBORN
ChemSusChem ◽  
2019 ◽  
Vol 13 (3) ◽  
pp. 501-512 ◽  
Author(s):  
Xing Fu ◽  
Yexin Hu ◽  
Yanru Zhang ◽  
Yucheng Zhang ◽  
Dianyong Tang ◽  
...  

2017 ◽  
Vol 15 (26) ◽  
pp. 5556-5563 ◽  
Author(s):  
William E. S. Hart ◽  
Leigh Aldous ◽  
Jason B. Harper

An ionic liquid is used to facilitate ether cleavage without the presence of side reactions; the microscopic origins of the solvent effects are examined. Controlled cleavage of this kind of ether is relevant in the fractionation of lignin.


1978 ◽  
Vol 43 (9) ◽  
pp. 1697-1705 ◽  
Author(s):  
Hans J. Reich ◽  
Susan Wollowitz ◽  
John E. Trend ◽  
Flora Chow ◽  
Daniel F. Wendelborn

ChemSusChem ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 434-434
Author(s):  
Xing Fu ◽  
Yexin Hu ◽  
Yanru Zhang ◽  
Yucheng Zhang ◽  
Dianyong Tang ◽  
...  

ChemSusChem ◽  
2020 ◽  
Vol 13 (3) ◽  
pp. 438-438
Author(s):  
Xing Fu ◽  
Yexin Hu ◽  
Yanru Zhang ◽  
Yucheng Zhang ◽  
Dianyong Tang ◽  
...  

Author(s):  
James F. Hainfeld ◽  
Frederic R. Furuya

Glutaraldehyde is a useful tissue and molecular fixing reagents. The aldehyde moiety reacts mainly with primary amino groups to form a Schiff's base, which is reversible but reasonably stable at pH 7; a stable covalent bond may be formed by reduction with, e.g., sodium cyanoborohydride (Fig. 1). The bifunctional glutaraldehyde, (CHO-(CH2)3-CHO), successfully stabilizes protein molecules due to generally plentiful amines on their surface; bovine serum albumin has 60; 59 lysines + 1 α-amino. With some enzymes, catalytic activity after fixing is preserved; with respect to antigens, glutaraldehyde treatment can compromise their recognition by antibodies in some cases. Complicating the chemistry somewhat are the reported side reactions, where glutaraldehyde reacts with other amino acid side chains, cysteine, histidine, and tyrosine. It has also been reported that glutaraldehyde can polymerize in aqueous solution. Newer crosslinkers have been found that are more specific for the amino group, such as the N-hydroxysuccinimide esters, and are commonly preferred for forming conjugates. However, most of these linkers hydrolyze in solution, so that the activity is lost over several hours, whereas the aldehyde group is stable in solution, and may have an advantage of overall efficiency.


1963 ◽  
Vol 10 (01) ◽  
pp. 106-119 ◽  
Author(s):  
E Beck ◽  
R Schmutzler ◽  
F Duckert ◽  

SummaryInhibitor of kallikrein and trypsin (KI) extracted from bovine parotis was compared with ε-aminocaproic acid (EACA): both substances inhibit fibrinolysis induced with streptokinase. EACA is a strong inhibitor of fibrinolysis in concentrations higher than 0, 1 mg per ml plasma. The same amount and higher concentrations are not able to inhibit completely the proteolytic-side reactions of fibrinolysis (fibrinogenolysis, diminution of factor V, rise of fibrin-polymerization-inhibitors). KI inhibits well proteolysis of plasma components in concentrations higher than 2,5 units per ml plasma. Much higher amounts of KI are needed to inhibit fibrinolysis as demonstrated by our in vivo and in vitro tests.Combination of the two substances for clinical use is suggested. Therapeutic possibilities are discussed.


Sign in / Sign up

Export Citation Format

Share Document