ChemInform Abstract: CHEMISTRY OF KETENE ACETALS. IV. A SIMPLE AND GENERAL METHOD FOR THE PREPARATION OF 4-HYDROXY-Γ-BUTYROLACTONES AND 2-BUTENOLIDES FROM 1,1-DIMETHOXYPROPENE AND α-ACYLOXY ALDEHYDES AND KETONES

1982 ◽  
Vol 13 (4) ◽  
Author(s):  
R. W. ABEN ◽  
R. HOFSTRAAT ◽  
J. W. SCHEEREN
Keyword(s):  
Aldehydes And Ketones ◽  
Ketene Acetals ◽  
General Method

α-Chymotrypsin-Induced Acetalization of Aldehydes and Ketones with Alcohols

Synthesis ◽  
2020 ◽  
Vol 52 (14) ◽  
pp. 2121-2126
Author(s):  
Zhanggao Le ◽  
Zongbo Xie ◽  
Jin Lan ◽  
Guofang Jiang ◽  
Jiangnan Yang ◽  
...  
Keyword(s):  
Catalytic Amount ◽  
First Report ◽  
Mild Conditions ◽  
Aldehydes And Ketones ◽  
Neutral Conditions ◽  
Induced Reaction ◽  
General Method

This is the first report of a simple and general method for acetalization­ of aldehydes via an α-chymotrypsin-induced reaction under mild conditions. A broad range of aromatic and heteroaromatic aldehydes have been acetalized under neutral conditions in good yields using a catalytic amount of chymotrypsin.

A Convenient General Method for the Preparation of Aldehydes and Ketones.

1964 ◽  
Vol 9 (1) ◽  
pp. 108-109 ◽  
Author(s):  
A. J. Sisti ◽  
John. Sawinski ◽  
Robert. Stout
Keyword(s):  
Aldehydes And Ketones ◽  
General Method

Reactions of Ketene Acetals. III. A New Synthesis of α-Pyrones. II

1975 ◽  
Vol 53 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Alain Bélanger ◽  
Paul Brassard
Keyword(s):  
Reaction Conditions ◽  
Unsaturated Aldehydes ◽  
New Synthesis ◽  
Aldehydes And Ketones ◽  
Ketene Acetals ◽  
By Products

The cycloaddition of chloroketene acetals to α, β-unsaturated aldehydes and ketones gives the corresponding 2,2-dialkoxy-3-chloro-3,4-dihydro-1,2-pyrans. Treatment of these compounds with alkoxides in dimethylsulfoxide or dimethylformamide yields α-pyrones directly. Some intermediates and by-products have been identified and the reaction conditions have been studied.

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