ChemInform Abstract: Quinone-Amine Reactions. Part 20. 1,4-Naphthoquinone Derivatives of Psychopharmacological Agents with Secondary Amine Structure.

1986 ◽  
Vol 17 (50) ◽  
Author(s):  
H.-J. KALLMAYER ◽  
C. TAPPE
2005 ◽  
Vol 70 (12) ◽  
pp. 2066-2074 ◽  
Author(s):  
Šárka Chalupová ◽  
Antonín Holý ◽  
Milena Masojídková

We have studied the reaction of 1-[2-(phosphonomethoxy)ethyl]cytosine (1) and its diisopropyl ester (2) with triethylammonium hydrogensulfite in 60% aqueous methanol. In the presence of some primary or secondary amine salts, at 25-70 °C, this reaction affords transaminated derivatives 4a-4e and 5a, 5b as main products accompanied by uracil compounds. However, with certain amines the reaction failed.


2015 ◽  
Vol 21 (4) ◽  
pp. 215-218 ◽  
Author(s):  
Zahra Arghiani ◽  
Seyed Mohammad Seyedi ◽  
Mehdi Bakavoli ◽  
Mohsen Nikpour

AbstractNew 10H-benzo[b]pyridazino[3,4-e][1,4]thiazines were prepared and evaluated for inhibitory activity against soybean 15-lipoxygenase enzyme. These compounds were synthesized by the sequential treatment of 4-bromo-3,6-dichloropyridazine with 2-aminothiophenol and a secondary amine with the subsequent heterocyclization in the presence of sodium amide.


2005 ◽  
Vol 43 (23) ◽  
pp. 5899-5905 ◽  
Author(s):  
Bungo Ochiai ◽  
Jun-ichi Nakayama ◽  
Masayuki Mashiko ◽  
Yoshiro Kaneko ◽  
Tomomi Nagasawa ◽  
...  

1967 ◽  
Vol 20 (8) ◽  
pp. 1643 ◽  
Author(s):  
RF Evans

Hexahydropyrimidine and some N-alkylated derivatives have been obtained from the reaction of the corresponding trimethylenediamine or its monoprotonated salt with formaldehyde. A variety of spectroscopic evidence supports a cyclic structure for these compounds in preference to a tautomeric open-chain form. The chemical behaviour of hexahydropyrimidine is explicable in terms of a cyclic di-secondary amine structure. The cyclic structure is destabilized with respect to the open- chain form if the hydrogen atoms attached to C2 of the hexahydropyrimidine ring are replaced by alkyl groups and cannot be detected when, in addition, one of the hydrogen atoms attached to nitrogen is replaced by the bulkier t-butyl group. Hexahydro-2-methylpyrimidine is dehydrogenated to 1,4,5,6- tetrahydro-2-methylpyrimidine on shaking with Adams catalyst and hydrogen under laboratory conditions. Hexahydropyrimidines which are tautomeric mixtures are reduced to the corresponding N-alkyl-1,3- diaminopropanes, while those possessing cyclic structures are inert.


2002 ◽  
Vol 58 (3) ◽  
pp. 545-552 ◽  
Author(s):  
Serap Beşli ◽  
Simon J. Coles ◽  
David B. Davies ◽  
Michael B. Hursthouse ◽  
Adem Kılıç ◽  
...  

A systematic study is presented on the products of aminolysis of N3P3Cl6 (1) and N3P3Ph2Cl4 (4) with dibenzylamine. Two series of mono- and disubstituted derivatives of compounds (1) and (4), namely N3P3Cl5[N(CH2Ph)2] (2) and N3P3Cl4[N(CH2Ph)2]2 (3) and N3P3Ph2Cl3[N(CH2Ph)2] (5) and N3P3Ph2Cl2[N(CH2Ph)2]2 (6) [where (2), (3), (5) and (6) are new structures], are investigated in order to determine whether steric or electronic effects prevail in the formation of dibenzylamino-substituted cyclophosphazenes. The influence of an electron-releasing group (i.e. phenyl) on the stereochemistry and degree of substitution of the product is analysed by comparison of the above two series. The difference in unsymmetrically substituted endocyclic P—N bond lengths, Δ, is used as a measure of the degree of the electronic contribution, in combination with basicity constants, to quantify the degree of the electron-releasing capacity of the R group. In order to compare geminal versus non-geminal substitution, a difunctional secondary amine was used to form the compound N3P3Cl4[NMe(CH2)3NMe] (7) (a reinvestigation) for inclusion in this study. It is shown that electron-releasing groups have a greater effect on the lengthening of P—Cl bonds as opposed to endocyclic P—N bonds and that this effect is greater in the non-geminal PRCl case than for geminal PCl2. However, steric effects are shown to be dominant in the reactions of dibenzylamine with N3P3 derivatives, with a disposition to a trans stereochemistry in bisdibenzylamino derivatives.


2015 ◽  
Vol 13 (42) ◽  
pp. 10548-10555 ◽  
Author(s):  
Tiina Laaksonen ◽  
Sami Heikkinen ◽  
Kristiina Wähälä

(+)-Dehydroabietylamine (1a), the novel derivatives (2a–6a) and their NTf2 salts (1b–6b) were tested as chiral NMR solvating agents for the resolution of enantiomers of Mosher's acid and other carboxylic acids, and their n-Bu4N salts.


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