ChemInform Abstract: o-Fluorobenzaldehyde-Chromium-Tricarbonyl: A New Chiral Complex for Highly Diastereoselective Nucleophilic Additions.

ChemInform ◽  
2010 ◽  
Vol 22 (22) ◽  
pp. no-no
Author(s):  
A. SOLLADIE-CAVALLO ◽  
M. BENCHEQROUN
Keyword(s):  
Nucleophilic Additions ◽  
Chromium Tricarbonyl ◽  
Chiral Complex

Metal-, and Organocatalyst-Free One-Pot Assembly of Chiral Aza-Tricyclic Molecules: Creating Six Contiguous Stereocenters from 2-D-Structures and an Amino Acid

2020 ◽  
Author(s):  
Dung Do
Keyword(s):  
Amino Acid ◽  
Chemical Space ◽  
Structural Diversity ◽  
Therapeutic Agents ◽  
Chiral Molecules ◽  
One Pot ◽  
Complex Molecules ◽  
Chiral Catalyst ◽  
Chiral Complex ◽  
Free Process

<p>Chiral molecules with their defined 3-D structures are of paramount importance for the study of chemical biology and drug discovery. Having rich structural diversity and unique stereoisomerism, chiral molecules offer a large chemical space that can be explored for the design of new therapeutic agents.<sup>1</sup> Practically, chiral architectures are usually prepared from organometallic and organocatalytic processes where a transition metal or an organocatalyst is tailor-made for desired reactions. As a result, developing a method that enables rapid assembly of chiral complex molecules under metal- and organocatalyst-free condition represents a daunting challenge. Here we developed a straightforward route to create a chiral 3-D structure from 2-D structures and an amino acid without any chiral catalyst. The center of this research is the design of a <a>special chiral spiroimidazolidinone cyclohexadienone intermediate</a>, a merger of a chiral reactive substrate with multiple nucleophillic/electrophillic sites and a transient organocatalyst. <a>This unique substrate-catalyst (“subcatalyst”) dual role of the intermediate enhances </a><a>the coordinational proximity of the chiral substrate and catalyst</a> in the key Aza-Michael/Michael cascade resulting in a substantial steric discrimination and an excellent overall diastereoselectivity. Whereas the “subcatalyst” (hidden catalyst) is not present in the reaction’s initial components, which renders a chiral catalyst-free process, it is strategically produced to promote sequential self-catalyzed reactions. The success of this methodology will pave the way for many efficient preparations of chiral complex molecules and aid for the quest to create next generation of therapeutic agents.</p>

ChemInform Abstract: Nucleophilic Additions to Pyridinium Salts. Reduction of the Intermediate Dihydropyridines.

ChemInform ◽  
2010 ◽  
Vol 25 (39) ◽  
pp. no-no
Author(s):  
R. LAVILLA ◽  
T. GOTSENS ◽  
F. GULLON ◽  
J. BOSCH
Keyword(s):  
Nucleophilic Additions ◽  
Pyridinium Salts

Application of FT-Raman spectroscopy to the study of selected organometallic complexes and proteins

1990 ◽  
Vol 68 (7) ◽  
pp. 1196-1200 ◽  
Author(s):  
Steven M. Barnett ◽  
François Dicaire ◽  
Ashraf A. Ismail
Keyword(s):  
Raman Spectroscopy ◽  
Near Infrared ◽  
Metal Carbonyl ◽  
Protein A ◽  
Organometallic Complexes ◽  
Laser Source ◽  
Chromium Tricarbonyl ◽  
Ft Raman Spectroscopy ◽  
Arene Chromium Tricarbonyl ◽  
Ft Raman

The study of colored organometallic complexes by dispersive Raman spectroscopy has been limited due to fluorescence or photodecomposition caused by the visible laser used as the excitation source. As a solution to this problem, FT-Raman spectroscopy with a near-infrared laser source has been useful in lowering fluorescence or photolysis in these samples. To investigate the utility of this technique, we have obtained and assigned the FT-Raman spectra of a series of arene chromium tricarbonyl complexes and of cyclopentadienyl manganese tricarbonyl. Some bands previously unobserved by dispersive Raman spectroscopy were seen, including a band assigned to a 13CO satellite in the spectrum of methylbenzoate chromium tricarbonyl. In addition, FT-Raman data for bovine serum albumin (BSA) and Protein-A are presented. Keywords: FT-Raman spectroscopy, metal carbonyl, proteins, organometallics, near infrared.

Nucleophilic Additions toN-Glycosylnitrones. Asymmetric Synthesis of ?-Aminophosphonic Acids

1985 ◽  
Vol 68 (6) ◽  
pp. 1730-1747 ◽  
Author(s):  
Rolf Huber ◽  
Andreas Knierzinger ◽  
Jean-Pierre Obrecht ◽  
Andrea Vasella
Keyword(s):  
Asymmetric Synthesis ◽  
Nucleophilic Additions ◽  
Aminophosphonic Acids

{.eta.6-(Organosilyl)arene}chromium tricarbonyl complexes: synthesis, characterization, and electrochemistry

1992 ◽  
Vol 11 (3) ◽  
pp. 1210-1220 ◽  
Author(s):  
Moises Moran ◽  
Isabel Cuadrado ◽  
Maria Carmen Pascual ◽  
Carmen Maria Casado ◽  
Jose Losada
Keyword(s):  
Chromium Tricarbonyl ◽  
Chromium Tricarbonyl Complexes ◽  
Arene Chromium Tricarbonyl

ChemInform Abstract: Nucleophilic Additions to 5-Hydroxymethyl-2-pyrrolidinone: Synthesis of Chiral 2,5-Disubstituted Pyrrolidines.

ChemInform ◽  
2010 ◽  
Vol 26 (20) ◽  
pp. no-no
Author(s):  
K. H. AHN ◽  
G. J. KWON ◽  
W. CHOI ◽  
S. J. LEE ◽  
D. J. YOO
Keyword(s):  
Nucleophilic Additions
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