ChemInform Abstract: Chiral N,N-Dialkylnorephedrines as Catalysts of the Highly Enantioselective Addition of Dialkylzincs to Aliphatic and Aromatic Aldehydes. The Asymmetric Synthesis of Secondary Aliphatic and Aromatic Alcohols of High Optical Purity.

ChemInform ◽  
2010 ◽  
Vol 22 (46) ◽  
pp. no-no
Author(s):  
K. SOAI ◽  
S. YOKOYAMA ◽  
T. HAYASAKA
Keyword(s):  
Asymmetric Synthesis ◽  
Optical Purity ◽  
Aromatic Aldehydes ◽  
High Optical Purity ◽  
Aromatic Alcohols ◽  
Enantioselective Addition

Asymmetric Synthesis of 2,2,2-Trifluorophenylethanol of High Optical Purity

Synthesis ◽  
1975 ◽  
Vol 1975 (11) ◽  
pp. 701-701 ◽  
Author(s):  
D. NASIPURI ◽  
Pranab K. BHATTACHARYA
Keyword(s):  
Asymmetric Synthesis ◽  
Optical Purity ◽  
High Optical Purity

scholarly journals Asymmetric synthesis with "privileged" ligands

2001 ◽  
Vol 73 (2) ◽  
pp. 325-329 ◽  
Author(s):  
Marco Bandini ◽  
Pier Giorgio Cozzi ◽  
Achille Umani-Ronchi
Keyword(s):  
Open Access ◽  
Asymmetric Synthesis ◽  
Carbonyl Compounds ◽  
Aromatic Aldehydes ◽  
Redox Processes ◽  
Asymmetric Allylation ◽  
Salen Complexes ◽  
Allyl Halides ◽  
Different Types ◽  
Enantioselective Addition

Different types of chiral "privileged" ligands 1 and 2 in promoting enantioselective addition of allylating agents to aliphatic and aromatic aldehydes are described. Here, a new concept in the asymmetric allylation reaction is presented. Redox [Cr (Salen) ] mediated addition of allyl halides to carbonyl compounds is described, and mechanistic investigations are discussed. These results open access to the fascinating area of the catalytic redox processes mediated by metallo-Salen complexes.

Glyoxylic acid derivatives in asymmetric synthesis

2000 ◽  
Vol 72 (9) ◽  
pp. 1589-1596 ◽  
Author(s):  
Janusz Jurczak ◽  
Tomasz Bauer
Keyword(s):  
Natural Products ◽  
Asymmetric Synthesis ◽  
Glyoxylic Acid ◽  
Optical Purity ◽  
Organic Syntheses ◽  
High Optical Purity ◽  
Derivatives Of

Synthesis of chiral derivatives of glyoxylic acid with special emphasis on N-glyoxyloyl-(2R)-bornane-10,2-sultam is presented. Investigation of glyoxylic acid chiral derivatives in various stereocontrolled organic syntheses showed their excellent ability to provide products of high optical purity. Application of our methodology to the synthesis of natural products and their analogs is presented.

Diels–Alder addition of the fumarate and acrylate of S-methyl lactate to α-hydroxy orthoquinodimethanes

1989 ◽  
Vol 67 (4) ◽  
pp. 574-579 ◽  
Author(s):  
James L. Charlton ◽  
Guy L. Plourde ◽  
Kevin Koh ◽  
Anthony S. Secco
Keyword(s):  
Asymmetric Synthesis ◽  
Optical Purity ◽  
Diels Alder ◽  
Asymmetric Induction ◽  
Synthetic Route ◽  
Methyl Lactate ◽  
High Optical Purity ◽  
Single Diastereomer ◽  
Potential Use

The cycloaddition of α-hydroxy orthoquinodimethane, generated photochemically from 2-methylbenzaldehyde, to the fumarate and acrylate of S-methyl lactate has been found to give a single diastereomer with high asymmetric induction (>95% de). This reaction provides a new and versatile synthetic route to substituted tetralins of high optical purity. A trans stereochemistry between the vicinal hydroxyl and carboxylactyl groups has been established for these cycloadducts. This is in contrast to previous work where cis stereochemistry has always been found for major cycloadducts of α-hydroxy o-QDMs. The high asymmetric induction, unusual diastereoselectivity, and the potential use of these reactions in asymmetric synthesis are discussed. Keywords: o-quinodimethanes, Diels–Alder, asymmetric, cycloaddition, induction, diastereoselective.

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