ChemInform Abstract: Design, Synthesis, and Kinetic Evaluation of a Unique Class of Elastase Inhibitors, the Peptidyl α-Ketobenzoxazoles, and the X- Ray Crystal Structure of the Covalent Complex Between Porcine Pancreatic Elastase and Ac-Ala-Pro-Val-2-Ben

ChemInform ◽  
2010 ◽  
Vol 23 (27) ◽  
pp. no-no
Author(s):  
P. D. EDWARDS ◽  
E. F. JUN. MEYER ◽  
J. VIJAYALAKSHMI ◽  
P. A. TUTHILL ◽  
D. A. ANDISIK ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Design Synthesis ◽  
Kinetic Evaluation ◽  
Pancreatic Elastase ◽  
X Ray ◽  
Porcine Pancreatic Elastase ◽  
Covalent Complex

Crystal structure of the covalent complex formed by a peptidyl α,α-difluoro-β-keto amide with porcine pancreatic elastase at 1.78 Å resolution

Peptides ◽  
1988 ◽  
pp. 344-345
Author(s):  
Lori H. Takahashi ◽  
R. Radhakrishnan ◽  
Edgar F. Meyer ◽  
Diane Amy Trainor
Keyword(s):  
Crystal Structure ◽  
Pancreatic Elastase ◽  
Porcine Pancreatic Elastase ◽  
Covalent Complex

ChemInform Abstract: Crystal Structure of the Covalent Complex Formed by a Peptidyl α,α-Difluoro-β-keto Amide (I) with Porcine Pancreatic Elastase at 1.78-Å Resolution

ChemInform ◽  
1989 ◽  
Vol 20 (32) ◽  
Author(s):  
L. H. TAKAHASHI ◽  
R. RADHAKRISHNAN ◽  
R. E. JUN. ROSENFIELD ◽  
E. F. JUN. MEYER ◽  
D. A. TRAINOR
Keyword(s):  
Crystal Structure ◽  
Pancreatic Elastase ◽  
Porcine Pancreatic Elastase ◽  
Covalent Complex

Crystal structure of the covalent complex formed by a peptidyl .alpha.,.alpha.-difluoro-.beta.-keto amide with porcine pancreatic elastase at 1.78 .ANG. resolution

1989 ◽  
Vol 111 (9) ◽  
pp. 3368-3374 ◽  
Author(s):  
Lori H. Takahashi ◽  
R. Radhakrishnan ◽  
Richard E. Rosenfield ◽  
Edgar F. Meyer ◽  
Diane Amy Trainor
Keyword(s):  
Crystal Structure ◽  
Pancreatic Elastase ◽  
Porcine Pancreatic Elastase ◽  
Covalent Complex

Design, Synthesis, and X-ray Crystal Structure of a Potent Dual Inhibitor of Thymidylate Synthase and Dihydrofolate Reductase as an Antitumor Agent1

2000 ◽  
Vol 43 (21) ◽  
pp. 3837-3851 ◽  
Author(s):  
Aleem Gangjee ◽  
Jianming Yu ◽  
John J. McGuire ◽  
Vivian Cody ◽  
Nikolai Galitsky ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Dual Inhibitor ◽  
Design Synthesis ◽  
X Ray

Design, synthesis and biological evaluation of novel human monoamine oxidase B inhibitors based on a fragment in an X-ray crystal structure

2019 ◽  
Vol 29 (8) ◽  
pp. 1012-1018 ◽  
Author(s):  
Kai Cheng ◽  
Shiyu Li ◽  
Xiao Lv ◽  
Yongbin Tian ◽  
Haiyan Kong ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Monoamine Oxidase ◽  
Biological Evaluation ◽  
Monoamine Oxidase B ◽  
Design Synthesis ◽  
X Ray ◽  
Synthesis And Biological Evaluation

Design, synthesis, and kinetic evaluation of high-affinity FKBP ligands and the X-ray crystal structures of their complexes with FKBP12

1993 ◽  
Vol 115 (22) ◽  
pp. 9925-9938 ◽  
Author(s):  
Dennis A. Holt ◽  
Juan I. Luengo ◽  
Dennis S. Yamashita ◽  
Hye Ja Oh ◽  
Arda L. Konialian ◽  
...  
Keyword(s):  
Crystal Structures ◽  
Design Synthesis ◽  
Kinetic Evaluation ◽  
X Ray ◽  
High Affinity

Human leukocyte and porcine pancreatic elastase: x-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors

Biochemistry ◽  
1989 ◽  
Vol 28 (5) ◽  
pp. 1951-1963 ◽  
Author(s):  
Wolfram Bode ◽  
Edgar Meyer ◽  
James C. Powers
Keyword(s):  
Substrate Specificity ◽  
Crystal Structures ◽  
Human Leukocyte ◽  
Pancreatic Elastase ◽  
X Ray ◽  
Porcine Pancreatic Elastase

X-ray diffraction analysis of the inhibition of porcine pancreatic elastase by a peptidyl trifluoromethylketone

1988 ◽  
Vol 201 (2) ◽  
pp. 423-428 ◽  
Author(s):  
Lori H. Takahashi ◽  
R. Radhakrishnan ◽  
Richard E. Rosenfield ◽  
Edgar F. Meyer ◽  
Diane Amy Trainor ◽  
...  
Keyword(s):  
Diffraction Analysis ◽  
X Ray Diffraction ◽  
Pancreatic Elastase ◽  
X Ray ◽  
Porcine Pancreatic Elastase
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