ChemInform Abstract: Synthetic Studies on the Common C25 Long Chain Acid Portion of Zooxanthellatoxins from a Symbiotic Dinoflagellate Symbiodinium sp.

The venom of an Australian elapid snake, the common death adder (Acanthophis antarcticus), was chromatographed on a CM-cellulose CM52 column. One of the neurotoxic components, Acanthophis antarcticus b (toxin Aa b) was isolated in about 9.4% (A280) yield. The complete amino acid sequence of toxin Aa b was elucidated. Toxin Aa b is composed of 73 amino acid residues, with ten half-cystine residues, and has a formula weight of 8135. Toxin Aa b has no histidine or methionine residue in its sequence. The amino acid sequence of toxin Aa b is homologous with those of other neurotoxins with known sequences, although it is novel in having a valine residue at its N-terminus and an arginine residue at position-23, where a lysine residue is found in almost all the so-far-known neurotoxins. Irrespective of the latter replacement, the toxin Aa b is fully active, with an LD50 value (in mice) of 0.13 microgram/g body weight on intramuscular injection.

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Latitudinal variation in the symbiotic dinoflagellate Symbiodinium of the common reef zoantharian Palythoa tuberculosa on the Saudi Arabian coast of the Red Sea

Journal of Biogeography ◽

10.1111/jbi.12795 ◽

2016 ◽

Vol 44 (3) ◽

pp. 661-673 ◽

Cited By ~ 24

Author(s):

James D. Reimer ◽

Marcela Herrera ◽

Remy Gatins ◽

May B. Roberts ◽

John E. Parkinson ◽

...

Keyword(s):

Red Sea ◽

Saudi Arabian ◽

Latitudinal Variation ◽

Symbiotic Dinoflagellate ◽

The Common

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Lituarine Synthetic Studies. An Efficient, Stereocontrolled Construction of the Common C(7−19) Tricyclic Spiroketal Fragment

Organic Letters ◽

10.1021/ol016948v ◽

2001 ◽

Vol 3 (24) ◽

pp. 3979-3982 ◽

Cited By ~ 9

Author(s):

Amos B. Smith ◽

Michael Frohn

Keyword(s):

The Common ◽

Synthetic Studies

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Synthetic Studies Toward Chiral Aromatic Triynes as Key Substrates for the Asymmetric Synthesis of Helicene-Like Molecules

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc20042193 ◽

2004 ◽

Vol 69 (12) ◽

pp. 2193-2211 ◽

Cited By ~ 7

Author(s):

Zuzana Alexandrová ◽

Irena G. Stará ◽

Petr Sehnal ◽

Filip Teplý ◽

Ivo Starý ◽

...

Keyword(s):

Transition Metal ◽

Metal Complexes ◽

Asymmetric Synthesis ◽

Transition Metal Complexes ◽

Sonogashira Coupling ◽

The Common ◽

Synthetic Studies ◽

Methyl Naphthalene ◽

Substituted 1

We have developed the synthesis of model nonracemic aromatic triynes (-)-(S)-1-4 containing the 1-{[2-(but-3-yn-1-yl)-1-naphthyl]ethynyl}-2-{[((S)-1-methylprop-2-yn-1-yl)oxy]- methyl}naphthalene unit. The common 1,2-di(2-substituted-1-naphthyl)acetylene part was constructed via Sonogashira coupling of appropriate 1-iodonaphthalenes with 1-ethynylnaphthalenes both bearing tethered acetylene units in positions 2. The chirality of triynes (-)-(S)-1-4 was introduced by incorporating commercially available (-)-(S)-but-3-yn-2-ol (10) into tethered acetylene units. The nonracemic triynes are intended to be used as substrates in stereoselective [2+2+2] triyne cycloisomerization catalyzed by transition metal complexes.

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