ChemInform Abstract: LiCl Catalyzed Knoevenagel Condensation: Comparative Study of Conventional Method vs Microwave Irradiation.

ChemInform ◽  
2010 ◽  
Vol 29 (52) ◽  
pp. no-no
Author(s):  
G. SABITHA ◽  
B. V. S. REDDY ◽  
R. S. BABU ◽  
J. S. YADAV
Keyword(s):  
Microwave Irradiation ◽  
Comparative Study ◽  
Conventional Method ◽  
Knoevenagel Condensation

LiCl Catalyzed Knoevenagel Condensation: Comparative Study of Conventional method vs Microwave Irradiation

1998 ◽  
Vol 27 (8) ◽  
pp. 773-774 ◽  
Author(s):  
Gowravaram Sabitha ◽  
B. V. Subba Reddy ◽  
R. Satheesh Babu ◽  
J. S. Yadav
Keyword(s):  
Microwave Irradiation ◽  
Comparative Study ◽  
Conventional Method ◽  
Knoevenagel Condensation

scholarly journals Comparative Study of Chemical Synthesis of Dihydropyrimidine (DHPMS) Derivatives by Biginelli Reaction Using Microwave Irradiation and Conventional Method

2013 ◽  
Vol 10 ◽  
pp. 7-11
Author(s):  
Ratnamala P. Sonawane
Keyword(s):  
Microwave Irradiation ◽  
Comparative Study ◽  
Conventional Method ◽  
Antitumor Agents ◽  
Wide Spectrum ◽  
Biginelli Reaction ◽  
High Yield ◽  
Melting Points ◽  
Aldehyde Derivative ◽  
Biological Actions

The majority of the drugs on the market today are entirely chemically synthesized in the laboratory. Several scientists had synthesized dihydropyrimidine (DHPMs) derivatives showing a wide spectrum of biological actions as antibacterials, antivirals as well as antitumor agents. This activity is principally due to presence of steriogenic carbon C4 in their structure. The current investigation is comparative study of chemically synthesis of two DHPMs derivatives by Biginelli Reaction using microwave irradiation and conventional method. The synthesis of DHPMsderivativeinvolves a multicomponent reaction (aldehyde derivative, urea/thiourea and 1,3-dicarbonyl compounds) in presence of HCl/NH4Cl as a catalyst. Two derivative viz. 3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones were synthesized and characterized using IR. The melting points were obtained are 203 °C and 211 °C respectively. Microwave irradiation was easy and gave more yield than conventional method. This study will help to develop easy protocol for the synthesis of many more DHPMs derivative with high yield.

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