ChemInform Abstract: A Chiral, Oxidatively Cleavable Auxiliary in Conjugate Additions of Lithium Amides. Preparation of Enantiomerically Pure β-Amino Acid Derivatives.

ChemInform ◽  
2010 ◽  
Vol 31 (35) ◽  
pp. no-no
Author(s):  
Joachim Podlech
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Conjugate Additions ◽  
Enantiomerically Pure ◽  
Lithium Amides

Peptide deformylase as biocatalyst for the synthesis of enantiomerically pure amino acid derivatives

2004 ◽  
Vol 29 (1-6) ◽  
pp. 265-277 ◽  
Author(s):  
Theo Sonke ◽  
Bernard Kaptein ◽  
A.F.Volker Wagner ◽  
Peter J.L.M Quaedflieg ◽  
Sabine Schultz ◽  
...  
Keyword(s):  
Amino Acid ◽  
Peptide Deformylase ◽  
Amino Acid Derivatives ◽  
Enantiomerically Pure ◽  
Pure Amino Acid

N-Methylamino acids in peptide synthesis. V. The synthesis of N-tert-butyloxycarbonyl, N-methylamino acids by N-methylation

1977 ◽  
Vol 55 (5) ◽  
pp. 906-910 ◽  
Author(s):  
S. T. Cheung ◽  
N. Leo Benoiton
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Methyl Iodide ◽  
Peptide Synthesis ◽  
Room Temperature ◽  
Sodium Hydride ◽  
Amino Acid Derivatives ◽  
Enantiomerically Pure ◽  
Neutral Amino Acids ◽  
Related Data

The preparation of enantiomerically pure N-tert-butyloxycarbonyl,N-methylamino acids by N-methylation of the parent amino acid derivatives using sodium hydride and methyl iodide in tetrahydrofuran at room temperature is described for neutral amino acids including O-benzyl-protected threonine and tyrosine. Methylation of the O-benzylserine derivative under these conditions gives the N-methyldehydroalanine derivative. The β-elimination is completely suppressed, giving the corresponding N-methylserine derivative when the reaction is carried out at 5 °C. Other related data on N-methylation and N-methylamino acid derivatives are presented.

Improved Preparation of Enantiomerically Pure 5-Oxo Amino Acid Derivatives by Palladium-Catalysed Coupling Reactions

Synlett ◽  
1995 ◽  
Vol 1995 (08) ◽  
pp. 819-820 ◽  
Author(s):  
Joanne L. Fraser ◽  
Richard F. W. Jackson ◽  
Barry Porter
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Coupling Reactions ◽  
Enantiomerically Pure
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