Peptide deformylase as biocatalyst for the synthesis of enantiomerically pure amino acid derivatives

2004 ◽  
Vol 29 (1-6) ◽  
pp. 265-277 ◽  
Author(s):  
Theo Sonke ◽  
Bernard Kaptein ◽  
A.F.Volker Wagner ◽  
Peter J.L.M Quaedflieg ◽  
Sabine Schultz ◽  
...  
Keyword(s):  
Amino Acid ◽  
Peptide Deformylase ◽  
Amino Acid Derivatives ◽  
Enantiomerically Pure ◽  
Pure Amino Acid

N-Methylamino acids in peptide synthesis. V. The synthesis of N-tert-butyloxycarbonyl, N-methylamino acids by N-methylation

1977 ◽  
Vol 55 (5) ◽  
pp. 906-910 ◽  
Author(s):  
S. T. Cheung ◽  
N. Leo Benoiton
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Methyl Iodide ◽  
Peptide Synthesis ◽  
Room Temperature ◽  
Sodium Hydride ◽  
Amino Acid Derivatives ◽  
Enantiomerically Pure ◽  
Neutral Amino Acids ◽  
Related Data

The preparation of enantiomerically pure N-tert-butyloxycarbonyl,N-methylamino acids by N-methylation of the parent amino acid derivatives using sodium hydride and methyl iodide in tetrahydrofuran at room temperature is described for neutral amino acids including O-benzyl-protected threonine and tyrosine. Methylation of the O-benzylserine derivative under these conditions gives the N-methyldehydroalanine derivative. The β-elimination is completely suppressed, giving the corresponding N-methylserine derivative when the reaction is carried out at 5 °C. Other related data on N-methylation and N-methylamino acid derivatives are presented.

Improved Preparation of Enantiomerically Pure 5-Oxo Amino Acid Derivatives by Palladium-Catalysed Coupling Reactions

Synlett ◽  
1995 ◽  
Vol 1995 (08) ◽  
pp. 819-820 ◽  
Author(s):  
Joanne L. Fraser ◽  
Richard F. W. Jackson ◽  
Barry Porter
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Coupling Reactions ◽  
Enantiomerically Pure

scholarly journals Asymmetric Synthesis of α,α-Difluoro-β-amino Acid Derivatives from Enantiomerically Pure N-tert-Butylsulfinimines.

ChemInform ◽  
2003 ◽  
Vol 34 (16) ◽  
Author(s):  
Donnette D. Staas ◽  
Kelly L. Savage ◽  
Carl F. Homnick ◽  
Nancy N. Tsou ◽  
Richard G. Ball
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Amino Acid Derivatives ◽  
Enantiomerically Pure

Efficient chemoenzymatic synthesis of enantiomerically pure β-heterocyclic amino acid derivatives

2000 ◽  
Vol 11 (23) ◽  
pp. 4719-4724 ◽  
Author(s):  
Valérie Rolland-Fulcrand ◽  
Nicolas Haroune ◽  
Maire Louise Roumestant ◽  
Jean Martinez
Keyword(s):  
Amino Acid ◽  
Chemoenzymatic Synthesis ◽  
Amino Acid Derivatives ◽  
Enantiomerically Pure

ChemInform Abstract: Efficient Chemoenzymatic Synthesis of Enantiomerically Pure β-Heterocyclic Amino Acid Derivatives.

ChemInform ◽  
2001 ◽  
Vol 32 (20) ◽  
pp. no-no
Author(s):  
Valerie Rolland-Fulcrand ◽  
Nicolas Haroune ◽  
Marie-Louise Roumestant ◽  
Jean Martinez
Keyword(s):  
Amino Acid ◽  
Chemoenzymatic Synthesis ◽  
Amino Acid Derivatives ◽  
Enantiomerically Pure

ChemInform Abstract: An Improved Method for the Synthesis of Enantiomerically Pure Amino Acid Ester Isocyanates.

ChemInform ◽  
2010 ◽  
Vol 24 (20) ◽  
pp. no-no
Author(s):  
J. S. NOWICK ◽  
N. A. POWELL ◽  
T. M. NGUYEN ◽  
G. NORONHA
Keyword(s):  
Amino Acid ◽  
Acid Ester ◽  
Amino Acid Ester ◽  
Improved Method ◽  
Enantiomerically Pure ◽  
Pure Amino Acid

scholarly journals Structural Characterization of an Enantiomerically Pure Amino Acid Imidazolide and Direct Formation of the β-Lactam Nucleus from an α-Amino Acid

2008 ◽  
Vol 10 (3) ◽  
pp. 369-372 ◽  
Author(s):  
Brian S. Gerstenberger ◽  
Jinzhen Lin ◽  
Yvette S. Mimieux ◽  
Lauren E. Brown ◽  
Allen G. Oliver ◽  
...  
Keyword(s):  
Amino Acid ◽  
Structural Characterization ◽  
Enantiomerically Pure ◽  
Direct Formation ◽  
Pure Amino Acid
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