ChemInform Abstract: The Synthesis and Structure-Activity Relationships of 1,3-Diaryl 1,2,4-(4H)-Triazol-5-ones: A New Class of Calcium-Dependent, Large Conductance, Potassium (Maxi-K) Channel Opener Targeted for Urge Urinary Incontinence.

Calcium Dependent ◽

New Class ◽

Structure Activity ◽

Channel Opener ◽

The synthesis and structure–activity relationships of 1,3-diaryl 1,2,4-(4 H )-triazol-5-ones: A new class of calcium-dependent, large conductance, potassium (maxi-k) channel opener targeted for urge urinary incontinence

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00099-9 ◽

2002 ◽

Vol 12 (7) ◽

pp. 1117-1120 ◽

Cited By ~ 26

Author(s):

Piyasena Hewawasam ◽

Matthew Erway ◽

George Thalody ◽

Harvey Weiner ◽

Christopher G Boissard ◽

...

Keyword(s):

Urinary Incontinence ◽

Urge Urinary Incontinence ◽

K Channel ◽

Calcium Dependent ◽

New Class ◽

Structure Activity ◽

Channel Opener ◽

The Discovery of a New Class of Large-Conductance Ca2+-Activated K+ Channel Opener Targeted for Overactive Bladder: Synthesis and Structure—Activity Relationships of 2-Amino-4-azaindoles.

ChemInform ◽

10.1002/chin.200339131 ◽

2003 ◽

Vol 34 (39) ◽

Author(s):

Sean C. Turner ◽

et al. et al.

Keyword(s):

Overactive Bladder ◽

K Channel ◽

New Class ◽

Structure Activity ◽

Channel Opener ◽

The discovery of a new class of large-conductance Ca2+-activated K+ channel opener targeted for overactive bladder: synthesis and structure–activity relationships of 2-amino-4-azaindoles

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(03)00324-x ◽

2003 ◽

Vol 13 (12) ◽

pp. 2003-2007 ◽

Cited By ~ 16

Author(s):

Sean C. Turner ◽

William A. Carroll ◽

Tammie K. White ◽

Murali Gopalakrishnan ◽

Michael J. Coghlan ◽

...

Keyword(s):

Overactive Bladder ◽

K Channel ◽

New Class ◽

Structure Activity ◽

Channel Opener ◽

Synthesis and Structure−Activity Relationships of 3-Aryloxindoles: A New Class of Calcium-Dependent, Large Conductance Potassium (Maxi-K) Channel Openers with Neuroprotective Properties

Journal of Medicinal Chemistry ◽

10.1021/jm0101850 ◽

2002 ◽

Vol 45 (7) ◽

pp. 1487-1499 ◽

Cited By ~ 125

Author(s):

Piyasena Hewawasam ◽

Matthew Erway ◽

Sandra L. Moon ◽

Jay Knipe ◽

Harvey Weiner ◽

...

Keyword(s):

K Channel ◽

Calcium Dependent ◽

New Class ◽

The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(02)00240-8 ◽

2002 ◽

Vol 12 (13) ◽

pp. 1779-1783 ◽

Cited By ~ 65

Author(s):

Piyasena Hewawasam ◽

Wenhong Fan ◽

Jay Knipe ◽

Sandra L Moon ◽

Christopher G Boissard ◽

...

Keyword(s):

K Channel ◽

Post Stroke ◽

Calcium Dependent ◽

New Class ◽

ChemInform Abstract: The Synthesis and Structure-Activity Relationships of 4-Aryl-3-aminoquinolin-2-ones: A New Class of Calcium-Dependent, Large Conductance, Potassium (Maxi-K) Channel Openers Targeted for Post-Stroke Neuroprotection.

ChemInform ◽

10.1002/chin.200244161 ◽

2010 ◽

Vol 33 (44) ◽

pp. no-no

Author(s):

Piyasena Hewawasam ◽

Wenhong Fan ◽

Jay Knipe ◽

Sandra L. Moon ◽

Christopher G. Boissard ◽

...

Keyword(s):

K Channel ◽

Post Stroke ◽

Calcium Dependent ◽

New Class ◽

Discovery and structure–activity relationships of a novel series of benzopyran-based KATP openers for urge urinary incontinence

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2008.11.055 ◽

2009 ◽

Vol 17 (2) ◽

pp. 855-866 ◽

Cited By ~ 7

Author(s):

Xuqing Zhang ◽

Yuhong Qiu ◽

Xiaojie Li ◽

Sheela Bhattacharjee ◽

Morgan Woods ◽

...

Keyword(s):

Urinary Incontinence ◽

Urge Urinary Incontinence ◽

Structure-activity relationship of a novel K+ channel opener, KRN4884, and related compounds in porcine coronary artery

General Pharmacology The Vascular System ◽

10.1016/0306-3623(95)02139-6 ◽

1996 ◽

Vol 27 (6) ◽

pp. 985-989 ◽

Cited By ~ 15

Author(s):

Hideakira Izumi ◽

Yoshihiro Tanaka ◽

Yuji Okada ◽

Nobuyuki Ogawa ◽

Toshio Izawa

Keyword(s):

Coronary Artery ◽

Structure Activity Relationship ◽

Activity Relationship ◽

K Channel ◽

Porcine Coronary Artery ◽

Structure Activity ◽

Channel Opener ◽

Relationship Of ◽

K Channel Opener ◽

Related Compounds

Evidence of Pharmacologic Preconditioning During PTCA by Intravenous Pre-treatment of ATP-sensitive K+ Channel Opener NICORANDIL

Journal of the American College of Cardiology ◽

10.1016/s0735-1097(97)87992-2 ◽

1998 ◽

Vol 31 (2) ◽

pp. 458A

Author(s):

H Matsuo

Keyword(s):

K Channel ◽

Channel Opener ◽

Pre Treatment ◽

Faculty Opinions recommendation of Characterization of a novel ATP-sensitive K+ channel opener, A-251179, on urinary bladder relaxation and cystometric parameters.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1086152.539136 ◽

2007 ◽

Author(s):

Rodolfo Testa

Keyword(s):

Urinary Bladder ◽

K Channel ◽

Channel Opener ◽