New Copper Chemistry. Part 31. Remarkable Effect of Silyl Groups on Asymmetric Induction in a Conjugate Addition Reaction with O-Methylnorephedrine-Based N-Silylamidocuprates.

ChemInform ◽  
2005 ◽  
Vol 36 (24) ◽  
Author(s):  
Steven H. Bertz ◽  
Craig A. Ogle ◽  
Abhinav Rastogi
Keyword(s):  
Addition Reaction ◽  
Conjugate Addition ◽  
Asymmetric Induction ◽  
Remarkable Effect ◽  
Silyl Groups

scholarly journals The Conjugate Addition Reaction

ChemInform ◽  
2005 ◽  
Vol 36 (44) ◽  
Author(s):  
A. Alexakis
Keyword(s):  
Addition Reaction ◽  
Conjugate Addition

ChemInform Abstract: Synthesis of β-Sulfanyl Ketones via a Tandem Rearrangement-Conjugate Addition Reaction Catalyzed by a Re(V)-Oxo Complex.

ChemInform ◽  
2013 ◽  
Vol 44 (22) ◽  
pp. no-no
Author(s):  
Alyson E. Garst ◽  
Alexandra D. Badiceanu ◽  
Kristine A. Nolin
Keyword(s):  
Addition Reaction ◽  
Conjugate Addition

Organocopper conjugate addition reaction in the presence of trimethylchlorosilane

1986 ◽  
Vol 27 (9) ◽  
pp. 1047-1050 ◽  
Author(s):  
A. Alexakis ◽  
J. Berlan ◽  
Y. Besace
Keyword(s):  
Addition Reaction ◽  
Conjugate Addition

A Concise Total Synthesis of (±)-Mesembrine

Synlett ◽  
2018 ◽  
Vol 29 (09) ◽  
pp. 1203-1206 ◽  
Author(s):  
Hyoungsu Kim ◽  
Hosam Choi ◽  
Kiyoun Lee
Keyword(s):  
Total Synthesis ◽  
Claisen Rearrangement ◽  
Addition Reaction ◽  
Conjugate Addition ◽  
Allylic Oxidation ◽  
Quaternary Stereocenter

A concise total synthesis of (±)-mesembrine has been successfully accomplished in seven steps and 24% overall yield from commercially available 3-ethoxy-2-cyclohexen-1-one. Central to the assembly of the skeleton of mesembrine are a Johnson–Claisen rearrangement for the formation of the benzylic quaternary stereocenter and direct allylic oxidation to generate the substrate for the amidation/transannular aza-conjugate addition reaction.

scholarly journals Michael Addition of Imidazole to α, β -Unsaturated Carbonyl/Cyano Compound

2018 ◽  
Vol 5 (1) ◽  
pp. 18-31
Author(s):  
Seetaram Mohapatra ◽  
Nilofar Baral ◽  
Nilima Priyadarsini Mishra ◽  
Pravati Panda ◽  
Sabita Nayak
Keyword(s):  
Organic Chemistry ◽  
Amino Acids ◽  
Anticancer Agents ◽  
Michael Addition ◽  
Addition Reaction ◽  
Bond Formation ◽  
Conjugate Addition ◽  
Michael Addition Reaction ◽  
Cyano Compounds ◽  
Nitrogen Bond

Introduction: Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry. Expalantion: Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs. Conclusion: This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.

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