ChemInform Abstract: Enantioselective Friedel-Crafts Alkylation Reaction of Indoles with α,β-Unsaturated Acyl Phosphonates Catalyzed by Chiral Phosphoric Acid.

ChemInform ◽  
2010 ◽  
Vol 41 (43) ◽  
pp. no-no
Author(s):  
Prabhakar Bachu ◽  
Takahiko Akiyama
Keyword(s):  
Phosphoric Acid ◽  
Alkylation Reaction ◽  
Chiral Phosphoric Acid ◽  
Unsaturated Acyl

Chiral phosphoric acid catalyzed enantioselective N-alkylation of indoles with in situ generated cyclic N-acyl ketimines

2018 ◽  
Vol 54 (66) ◽  
pp. 9230-9233 ◽  
Author(s):  
Lvye Zhang ◽  
Binqiang Wu ◽  
Zhangtao Chen ◽  
Jinjin Hu ◽  
Xiaofei Zeng ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Alkylation Reaction ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

A chiral SPINOL derived phosphoric acid-catalyzed asymmetric N-alkylation reaction of indoles with cyclic α-diaryl-substituted N-acyl imines, which are generated in situ from 3-aryl 3-hydroxyisoindo-linones, has been demonstrated.

Hypercrosslinking chiral Brønsted acids into porous organic polymers for efficient heterogeneous asymmetric organosynthesis

2021 ◽  
Author(s):  
Xiaoming Liu ◽  
Yuwei Zhang ◽  
Zhenwei Zhang ◽  
Si Ma ◽  
Ji Jia ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Alkylation Reaction ◽  
High Porosity ◽  
One Pot ◽  
Chiral Phosphoric Acid ◽  
Axially Chiral ◽  
Construction Strategy ◽  
Chiral Brønsted Acids ◽  
Hypercrosslinked Polymers ◽  
Excellent Stability

Here, we certificated a construction strategy for directly immobilizing the axially chiral phosphoric acid into hypercrosslinked polymers by one-pot Friedel-Crafts alkylation reaction. They have high porosity, excellent stability and tailorable...

Chiral Phosphoric Acid Catalyzed Highly Enantioselective Friedel–Crafts Alkylation Reaction of C3-Substituted Indoles to β,γ-Unsaturated α-Ketimino Esters

2015 ◽  
Vol 17 (3) ◽  
pp. 540-543 ◽  
Author(s):  
Bo Bi ◽  
Qin-Xin Lou ◽  
Yu-Yang Ding ◽  
Sheng-Wei Chen ◽  
Sha-Sha Zhang ◽  
...  
Keyword(s):  
Phosphoric Acid ◽  
Alkylation Reaction ◽  
Chiral Phosphoric Acid ◽  
Acid Catalyzed

scholarly journals A Molecular Stereostructure Descriptor Based On Spherical Projection

Synlett ◽  
2020 ◽  
Author(s):  
Shuo-Qing Zhang ◽  
Xin Hong ◽  
Li-Cheng Xu ◽  
Xin Li ◽  
Miao-Jiong Tang ◽  
...  
Keyword(s):  
Machine Learning ◽  
Phosphoric Acid ◽  
Asymmetric Catalysis ◽  
Van Der Waals ◽  
Chiral Phosphoric Acid ◽  
Key Features ◽  
Precise Representation ◽  
Spherical Projection

AbstractDescription of molecular stereostructure is critical for the machine learning prediction of asymmetric catalysis. Herein we report a spherical projection descriptor of molecular stereostructure (SPMS), which allows precise representation of the molecular van der Waals (vdW) surface. The key features of SPMS descriptor are presented using the examples of chiral phosphoric acid, and the machine learning application is demonstrated in Denmark’s dataset of asymmetric thiol addition to N-acylimines. In addition, SPMS descriptor also offers a color-coded diagram that provides straightforward chemical interpretation of the steric environment.

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