ChemInform Abstract: Microwave-Assisted Synthesis of 3-Aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-(1H,6H)-dione Libraries: Derivatives of Toxoflavin

ChemInform ◽  
2011 ◽  
Vol 42 (9) ◽  
pp. no-no
Author(s):  
Nick Todorovic ◽  
Andrew Giacomelli ◽  
John A. Hassell ◽  
Christopher S. Frampton ◽  
Alfredo Capretta
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of

scholarly journals Microwave-assisted synthesis of new imide- and formamide-derivatives of 2(3H)-benzoxazolinones and 2(3H)-benzothiazolinones

ARKIVOC ◽  
2017 ◽  
Vol 2017 (4) ◽  
pp. 315-329
Author(s):  
Khemissi Seddiki ◽  
Wassila Yahia ◽  
Messaoud Liacha ◽  
Andrea Defant ◽  
Denise Sighel ◽  
...  
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of

Microwave-assisted synthesis of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione libraries: derivatives of toxoflavin

2010 ◽  
Vol 51 (46) ◽  
pp. 6037-6040 ◽  
Author(s):  
Nick Todorovic ◽  
Andrew Giacomelli ◽  
John A. Hassell ◽  
Christopher S. Frampton ◽  
Alfredo Capretta
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of

Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4-d]pyrimidin-4-ylamines

2007 ◽  
Vol 48 (24) ◽  
pp. 4293-4296 ◽  
Author(s):  
Gareth W. Harbottle ◽  
Neil Feeder ◽  
Karl R. Gibson ◽  
Mel Glossop ◽  
Graham N. Maw ◽  
...  
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of

New chalcones and thiopyrimidine analogues derived from mefenamic acid: microwave-assisted synthesis, anti-HIV activity and cytotoxicity as antileukemic agents

2017 ◽  
Vol 72 (4) ◽  
pp. 249-256 ◽  
Author(s):  
Hanan A. Al-Hazam ◽  
Zeki A. Al-Shamkani ◽  
Najim A. Al-Masoudi ◽  
Bahjat A. Saeed ◽  
Christophe Pannecouque
Keyword(s):  
Mefenamic Acid ◽  
Leukemia Cells ◽  
Basic Medium ◽  
Microwave Assisted Synthesis ◽  
Schmidt Reaction ◽  
Microwave Assisted ◽  
Amide Derivatives ◽  
Derivatives Of ◽  
Anti Hiv ◽  
Hiv 1

AbstractThe development of new HIV non-nucleoside reverse transcriptase inhibitors offers the possibility of generating structures of increased potency. To this end, coupling of mefenamic acid (4) with 4-amino-acetophenone (6) in the presence of dicyclohexylcarbodiimide and dimethylaminopyridine (DMAP) reagents afforded 4-(acetyphenyl)-2-((2,3-dimethylphenyl)amino)benzamide (7). Analogously, treatment of mefenamyl chloride (5) prepared from 4 with 6 under microwave irradiation (MWI) afforded 7. A new series of substituted chalconyl-incorporated amide derivatives of mefenamic acid 8–13 were synthesized from condensation of 7 with various substituted benzaldehydes via the Claisen–Schmidt reaction. Treatment of 8 and 11 with thiourea in a basic medium afforded the thiopyrimidine analogues 14 and 15, respectively. The newly synthesized compounds were assayed against HIV-1 and HIV-2 in MT-4 cells. Compounds 9 and 11 showed cytotoxicity values of 2.17 and 2.06 μm, respectively, against mock-infected MT-4 cells (C type adult T leukemia cells), which considered to be promising antileukemic agents.

Microwave-assisted synthesis and antibacterial evaluation of new derivatives of 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

2016 ◽  
Vol 22 (1) ◽  
pp. 49-53
Author(s):  
Zahra Ebrahimpour ◽  
Ali Shiri ◽  
Mehdi Bakavoli ◽  
Seyed Mohammad Seyedi ◽  
Masoumeh Bahreini ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of ◽  
Antibacterial Evaluation

AbstractSynthesis of new 1,2-dihydro-3H-pyrazolo[3,4-d] pyrimidin-3-ones4–6starting with ethyl 4-hydroxy-2-methylthio-pyrimidine-5-carboxylate (1) under classical heating and microwave-induced conditions is reported. The antibacterial activities of the synthesized compounds were evaluated using chloramphenicol and streptomycin as reference drugs.

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