Microwave-assisted synthesis and antibacterial evaluation of new derivatives of 1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

2016 ◽  
Vol 22 (1) ◽  
pp. 49-53
Author(s):  
Zahra Ebrahimpour ◽  
Ali Shiri ◽  
Mehdi Bakavoli ◽  
Seyed Mohammad Seyedi ◽  
Masoumeh Bahreini ◽  
...  
Keyword(s):  
Antibacterial Activities ◽  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of ◽  
Antibacterial Evaluation

AbstractSynthesis of new 1,2-dihydro-3H-pyrazolo[3,4-d] pyrimidin-3-ones4–6starting with ethyl 4-hydroxy-2-methylthio-pyrimidine-5-carboxylate (1) under classical heating and microwave-induced conditions is reported. The antibacterial activities of the synthesized compounds were evaluated using chloramphenicol and streptomycin as reference drugs.

Microwave assisted synthesis of novel Pyrazole derivatives and their biological evaluation as anti-bacterial agents

2020 ◽  
Vol 23 ◽  
Author(s):  
Hadis Khodadad ◽  
Farhad Hatamjafari ◽  
Khalil Pourshamsian ◽  
Babak Sadeghi
Keyword(s):  
Antibacterial Activity ◽  
Aromatic Aldehydes ◽  
Catalytic Amount ◽  
Antibacterial Activities ◽  
Structural Features ◽  
Biological Evaluation ◽  
Aureus Strain ◽  
Microwave Assisted Synthesis ◽  
Pyrazole Derivatives ◽  
Microwave Assisted

Aim and Objective: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol. Materials and Methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR, 1H, 13C NMR and elemental analysis. Results: The antibacterial activities of the synthesized pyrazoles was evaluated against three gram-positive bacteria such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain and none of them demonstrated antibacterial activity against E. coli.

scholarly journals Microwave-assisted synthesis of new imide- and formamide-derivatives of 2(3H)-benzoxazolinones and 2(3H)-benzothiazolinones

ARKIVOC ◽  
2017 ◽  
Vol 2017 (4) ◽  
pp. 315-329
Author(s):  
Khemissi Seddiki ◽  
Wassila Yahia ◽  
Messaoud Liacha ◽  
Andrea Defant ◽  
Denise Sighel ◽  
...  
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of

ChemInform Abstract: Microwave-Assisted Synthesis of 3-Aryl-pyrimido[5,4-e][1,2,4]triazine-5,7-(1H,6H)-dione Libraries: Derivatives of Toxoflavin

ChemInform ◽  
2011 ◽  
Vol 42 (9) ◽  
pp. no-no
Author(s):  
Nick Todorovic ◽  
Andrew Giacomelli ◽  
John A. Hassell ◽  
Christopher S. Frampton ◽  
Alfredo Capretta
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of

scholarly journals Green Chemistry Approach for Efficient Synthesis of Schiff Bases of Isatin Derivatives and Evaluation of Their Antibacterial Activities

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Jnyanaranjan Panda ◽  
V. Jagannath Patro ◽  
Biswa Mohan Sahoo ◽  
Jitendriya Mishra
Keyword(s):  
Green Chemistry ◽  
Schiff Bases ◽  
Reaction Times ◽  
Antibacterial Activities ◽  
Primary Amines ◽  
Microwave Assisted Synthesis ◽  
Azomethine Group ◽  
Microwave Assisted ◽  
Isatin Derivatives

Microwave-assisted organic synthesis, a green chemistry approach, is nowadays widely used in the drug synthesis. Microwave-assisted synthesis improves both throughput and turnaround time for medicinal chemists by offering the benefits of drastically reduced reaction times, increased yields, and pure products. Schiff bases are the important class of organic compounds due to their flexibility, and structural diversities due to the presence of azomethine group which is helpful for elucidating the mechanism of transformation and rasemination reaction in biological system. This novel compound could also act as valuable ligands for the development of new chemical entities. In the present work, some Schiff bases of Isatin derivatives was synthesized using microwave heating method. Schiff base of Isatin were synthesized by condensation of the keto group of Isatin with different aromatic primary amines. They were characterized by means of spectral data and subsequently subjected to the in vitro antibacterial activities against gram positive and gram negative strains of microbes. It was observed that the compound with electron withdrawing substituents exhibited good antibacterial activities against almost all the micro organisms.

Microwave-assisted synthesis of 3-aryl-pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione libraries: derivatives of toxoflavin

2010 ◽  
Vol 51 (46) ◽  
pp. 6037-6040 ◽  
Author(s):  
Nick Todorovic ◽  
Andrew Giacomelli ◽  
John A. Hassell ◽  
Christopher S. Frampton ◽  
Alfredo Capretta
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of

Microwave-assisted synthesis of mGluR1 ligands: carbon, nitrogen and oxygen linked derivatives of pyrido[3,4-d]pyrimidin-4-ylamines

2007 ◽  
Vol 48 (24) ◽  
pp. 4293-4296 ◽  
Author(s):  
Gareth W. Harbottle ◽  
Neil Feeder ◽  
Karl R. Gibson ◽  
Mel Glossop ◽  
Graham N. Maw ◽  
...  
Keyword(s):  
Microwave Assisted Synthesis ◽  
Microwave Assisted ◽  
Derivatives Of
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