ChemInform Abstract: Bifunctional Primary Amine-Thiourea-TfOH (BPAT·TfOH) as a Chiral Phase-Transfer Catalyst: The Asymmetric Synthesis of Dihydropyrimidines.

ChemInform ◽  
2011 ◽  
Vol 42 (35) ◽  
pp. no-no
Author(s):  
Yangyun Wang ◽  
Jipan Yu ◽  
Zhiwei Miao ◽  
Ruyu Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Primary Amine ◽  
Phase Transfer ◽  
Phase Transfer Catalyst ◽  
Chiral Phase

Asymmetric synthesis of 3-phenyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-3-carbonitriles catalysed by phase transfer catalyst derived from tert-leucine.

Synlett ◽  
2021 ◽  
Author(s):  
Zhiqi Zhao ◽  
Jingdong Wang ◽  
lin zhong wei ◽  
gang jun cao ◽  
peng da liang ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Phase Transfer ◽  
Phase Transfer Catalyst ◽  
Chiral Phase ◽  
Phase Transfer Catalysts ◽  
Excellent Yield ◽  
Chiral Phase Transfer Catalysts

Chiral phase transfer catalysts derived from tert-leucine were synthesized and used in the aymmetric synthesis of 4-azaindoline derivatives. By this method, both enantiomers of corresponding products were obtained in excellent yield (up to 99%) with high enantioselectivity (up to 91% ee) and diastereoselectivity (up to >99: 1 dr).

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