Asymmetric synthesis of 3-phenyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-3-carbonitriles catalysed by phase transfer catalyst derived from tert-leucine.
Keyword(s):
Chiral phase transfer catalysts derived from tert-leucine were synthesized and used in the aymmetric synthesis of 4-azaindoline derivatives. By this method, both enantiomers of corresponding products were obtained in excellent yield (up to 99%) with high enantioselectivity (up to 91% ee) and diastereoselectivity (up to >99: 1 dr).
2018 ◽
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pp. 8704-8709
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