Bifunctional primary amine-thiourea–TfOH (BPAT·TfOH) as a chiral phase-transfer catalyst: the asymmetric synthesis of dihydropyrimidines

2011 ◽  
Vol 9 (8) ◽  
pp. 3050 ◽  
Author(s):  
Yangyun Wang ◽  
Jipan Yu ◽  
Zhiwei Miao ◽  
Ruyu Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Primary Amine ◽  
Phase Transfer ◽  
Phase Transfer Catalyst ◽  
Chiral Phase

Asymmetric synthesis of 3-phenyl-2,3-dihydro-1H-pyrrolo[3,2-b]pyridine-3-carbonitriles catalysed by phase transfer catalyst derived from tert-leucine.

Synlett ◽  
2021 ◽  
Author(s):  
Zhiqi Zhao ◽  
Jingdong Wang ◽  
lin zhong wei ◽  
gang jun cao ◽  
peng da liang ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Phase Transfer ◽  
Phase Transfer Catalyst ◽  
Chiral Phase ◽  
Phase Transfer Catalysts ◽  
Excellent Yield ◽  
Chiral Phase Transfer Catalysts

Chiral phase transfer catalysts derived from tert-leucine were synthesized and used in the aymmetric synthesis of 4-azaindoline derivatives. By this method, both enantiomers of corresponding products were obtained in excellent yield (up to 99%) with high enantioselectivity (up to 91% ee) and diastereoselectivity (up to >99: 1 dr).

Sign in / Sign up

Export Citation Format

Share Document