ChemInform Abstract: Broensted Acidic Ionic Liquid as an Efficient and Reusable Catalyst for One-Pot, Three-Component Synthesis of Pyrimidinone Derivatives via Biginelli-Type Reaction under Solvent-Free Conditions.

ChemInform ◽  
2011 ◽  
Vol 43 (2) ◽  
pp. no-no
Author(s):  
Abdol R. Hajipour ◽  
Yosof Ghayeb ◽  
Nafisehsadat Sheikhan ◽  
Arnold E. Ruoho
Keyword(s):  
Ionic Liquid ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
One Pot ◽  
Type Reaction ◽  
Acidic Ionic Liquid ◽  
Solvent Free Conditions

1, 1’-Sulfinyldiethylammonium Bis (Hydrogen Sulfate) as a Recyclable Dicationic Ionic Liquid Catalyst for the Efficient Solvent-free Synthesis of 3, 4-Dihydropyrimidin-2(1H)-ones via Biginelli Reaction

2020 ◽  
Vol 23 (2) ◽  
pp. 157-167
Author(s):  
Zainab Ehsani-Nasab ◽  
Ali Ezabadi
Keyword(s):  
Ionic Liquid ◽  
Biginelli Reaction ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
Hydrogen Sulfate ◽  
One Pot ◽  
Acidic Ionic Liquid ◽  
Brønsted Acidic Ionic Liquid ◽  
Solvent Free Conditions ◽  
Dicationic Ionic Liquid

Objective: A facile and efficient method for synthesis of 3, 4-dihydropyrimidin-2(1H)-ones via Biginelli reaction catalyzed by a novel dicationic Brönsted acidic ionic liquid, [(EtNH2)2SO][HSO4]2, has been successfully developed. Material and Method:: 3, 4-Dihydropyrimidin-2(1H)-ones were synthesized through one-pot condensation of aromatic aldehydes, ethyl acetoacetate, and urea under solvent-free conditions using [(EtNH2)2SO][HSO4]2 as a novel catalyst. The progress of the reaction was monitored by thin-layer chromatography (ethyl acetate / n-hexane = 1 / 5). The products have been characterized by IR, 1H NMR, 13C NMR, and also by their melting points. Results: In this research, a library of dihydropyrimidinone derivatives was synthesized via Biginelli reaction under solvent-free conditions at 120oC using [(EtNH2)2SO][HSO4]2 as a catalyst. Various aromatic aldehydes, as well as heteroaromatic aldehydes, were employed, affording good to high yields of the corresponding products and illustrating the substrate generality of the present method. In addition, the prepared dicationic Brönsted acidic ionic liquid can be easily recovered and reused. Conclusion: 1, 1’-Sulfinyldiethylammonium bis (hydrogen sulfate), as a novel dicationic ionic liquid, can act as a highly efficient catalyst for the synthesis of 3, 4-dihydropyrimidin-2(1H)-ones under solvent-free conditions.

ChemInform Abstract: Highly Efficient, One-Pot, Solvent-Free Synthesis of 2,4,6-Triarylpyridines Using a Broensted-Acidic Ionic Liquid as Reusable Catalyst.

ChemInform ◽  
2010 ◽  
Vol 42 (1) ◽  
pp. no-no
Author(s):  
Abolghasem Davoodnia ◽  
Mehdi Bakavoli ◽  
Raheleh Moloudi ◽  
Niloofar Tavakoli-Hoseini ◽  
Maryam Khashi
Keyword(s):  
Ionic Liquid ◽  
Solvent Free ◽  
Reusable Catalyst ◽  
One Pot ◽  
Acidic Ionic Liquid ◽  
Highly Efficient ◽  
Solvent Free Synthesis
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