ChemInform Abstract: Titanium-Mediated Direct Carbon-Carbon Double Bond Formation to α-Trifluoromethyl Acids: A New Contribution to the Knoevenagel Reaction and a High-Yielding and Stereoselective Synthesis of α-Trifluoromethylacrylic Acids.

ChemInform ◽  
2012 ◽  
Vol 43 (16) ◽  
pp. no-no
Author(s):  
Yanmei Liu ◽  
Hua Lai ◽  
Bo Rong ◽  
Tie Zhou ◽  
Jia Hong ◽  
...  
Keyword(s):  
Double Bond ◽  
Stereoselective Synthesis ◽  
Bond Formation ◽  
Knoevenagel Reaction ◽  
Carbon Double Bond

Neodymium-Promoted Highly Selective Carbon–Carbon Double Bond Formation of Ketones with Allyl Halides in the Presence of Diethyl Phosphite

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3446-3451
Author(s):  
Songlin Zhang ◽  
Dengbing Xie ◽  
Yiqiong Wang ◽  
Bo Yang
Keyword(s):  
Double Bond ◽  
Bond Formation ◽  
Point Of View ◽  
Diethyl Phosphite ◽  
Reaction Conditions ◽  
One Pot ◽  
Mild Conditions ◽  
Carbon Double Bond ◽  
Allyl Halides ◽  
First Time

The carbon–carbon double bond formation via neodymium-mediated Barbier-type reaction of ketones and allyl halides in the presence of diethyl phosphite is reported for the first time. The reaction is highly α-regioselective and was conveniently carried out under mild conditions in a one-pot fashion. From a synthetic point of view, a series of conjugated alkenes were obtained in moderate to good yields in this one-pot reaction with feasible reaction conditions.

ChemInform Abstract: Carbon-Carbon Double Bond Formation from a cis-Bis(chloromethyl) Complex.

ChemInform ◽  
2010 ◽  
Vol 23 (11) ◽  
pp. no-no
Author(s):  
J. L. HUBBARD ◽  
A. MORNEAU ◽  
R. M. BURNS ◽  
O. W. NADEAU
Keyword(s):  
Double Bond ◽  
Bond Formation ◽  
Carbon Double Bond
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