ChemInform Abstract: One-Pot Chemoselective Synthesis of 2,4,6,8-Tetrasubstituted Quinazolines via Microwave-Assisted Consecutive Bis-SNAr/Bis-Suzuki-Miyaura Cross-Coupling Reactions.

ChemInform ◽  
2014 ◽  
Vol 45 (50) ◽  
pp. no-no ◽  
Author(s):  
Youssef Kabri ◽  
Maxime D. Crozet ◽  
Sebastien Redon ◽  
Patrice Vanelle
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
One Pot ◽  
Microwave Assisted ◽  
Cross Coupling Reactions ◽  
Chemoselective Synthesis

A Revised Modular Approach to D8-THC and Derivatives Through Late-Stage Suzuki-Miyaura Cross-Coupling Reactions

2019 ◽  
Author(s):  
Victor Bloemendal ◽  
Floris P. J. T. Rutjes ◽  
Thomas J. Boltje ◽  
Daan Sondag ◽  
Hidde Elferink ◽  
...  
Keyword(s):  
Biological Activity ◽  
Late Stage ◽  
Medicinal Chemistry ◽  
Cross Coupling ◽  
Modular Approach ◽  
Coupling Reactions ◽  
One Pot ◽  
Biologically Relevant ◽  
Cross Coupling Reactions ◽  
Chemistry Research

<p>In this manuscript we describe a modular pathway to synthesize biologically relevant (–)-<i>trans</i>-Δ<sup>8</sup>-THC derivatives, which can be used to modulate the pharmacologically important CB<sub>1</sub> and CB<sub>2</sub> receptors. This pathway involves a one-pot Friedel-Crafts alkylation/cyclization protocol, followed by Suzuki-Miyaura cross-coupling reactions and gives rise to a series of new Δ<sup>8</sup>-THC derivatives. In addition, we demonstrate using extensive NMR evidence that similar halide-substituted Friedel-Crafts alkylation/cyclization products in previous articles were wrongly assigned as the para-isomers, which also has consequence for the assignment of the subsequent cross-coupled products and interpretation of their biological activity. </p> <p>Considering the importance of the availability of THC derivatives in medicinal chemistry research and the fact that previously synthesized compounds were wrongly assigned, we feel this research is describing a straightforward pathway into new cannabinoids.</p>

Microwave-Assisted Aqueous Suzuki Cross-Coupling Reactions

1999 ◽  
Vol 64 (11) ◽  
pp. 3885-3890 ◽  
Author(s):  
Carsten G. Blettner ◽  
Wilfried A. König ◽  
Wolfgang Stenzel ◽  
Theo Schotten
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Microwave Assisted ◽  
Cross Coupling Reactions

Chemoselective Synthesis of Arylpyridines through Suzuki-Miyaura Cross-Coupling Reactions

2018 ◽  
Vol 2018 (8) ◽  
pp. 990-1003 ◽  
Author(s):  
Rodisnel Perdomo Rivera ◽  
Peter Ehlers ◽  
Lars Ohlendorf ◽  
Eugenio Torres Rodríguez ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Chemoselective Synthesis

scholarly journals Synthesis of pentasubstituted 2-aryl pyrroles from boryl and stannyl alkynes via one-pot sequential Ti-catalyzed [2 + 2 + 1] pyrrole synthesis/cross coupling reactions

2020 ◽  
Vol 11 (37) ◽  
pp. 10236-10242
Author(s):  
Yukun Cheng ◽  
Channing K. Klein ◽  
Ian A. Tonks
Keyword(s):  
Small Molecule ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
One Pot ◽  
Cross Coupling Reactions

Multisubstituted pyrroles are commonly found in many bioactive small molecule scaffolds, yet the synthesis of highly-substituted pyrrole cores remains challenging.

Microwave-Assisted Heterogeneous Cross-Coupling Reactions Catalyzed by Nickel-in-Charcoal (Ni/C)

2006 ◽  
Vol 1 (3) ◽  
pp. 417-429 ◽  
Author(s):  
Bruce H. Lipshutz ◽  
Bryan A. Frieman ◽  
Ching-Tien Lee ◽  
Asher Lower ◽  
Danielle M. Nihan ◽  
...  
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
Microwave Assisted ◽  
Cross Coupling Reactions

Synthesis of Di-, Tri-, and Tetrasulfides through Multifold Carbon−Sulfur Cross-Coupling Reactions with Indium Tri(organothiolates) in a One-Pot Procedure

2011 ◽  
Vol 76 (3) ◽  
pp. 760-765 ◽  
Author(s):  
Phil Ho Lee ◽  
Youngchul Park ◽  
Sangkyun Park ◽  
Euijae Lee ◽  
Sunggak Kim
Keyword(s):  
Cross Coupling ◽  
Coupling Reactions ◽  
One Pot ◽  
Cross Coupling Reactions
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