An efficient and highly selective multicomponent synthesis of 4-aminoimidazo[1,2-a]triazines, which are 5-aza-7-deaza-isosteres of adenine, was developed.
A microwave assisted multicomponent protocol on water allows the regioselective synthesis of chiral aryl-1,2-mercaptoamines. The enzymatic resolution of the racemates leads to enantioenriched products.