ChemInform Abstract: Property-Guided Synthesis of Aza-Tricyclic Indolines: Development of Gold Catalysis en route.

ChemInform ◽  
2016 ◽  
Vol 47 (36) ◽  
Author(s):  
Patrick M. Barbour ◽  
Wei Wang ◽  
Le Chang ◽  
Kasey L. Pickard ◽  
Rana Rais ◽  
...  
Keyword(s):  
Gold Catalysis ◽  
Abstract Property

Gold Catalyzed Hydroamination of Propargylic Alcohols: Controlling Divergent Reaction Pathways to Access 1,3-Aminoalcohols, 3-Hydroxyketones or 3-Aminoketones

2018 ◽  
Author(s):  
Victor Laserna ◽  
Tom Sheppard
Keyword(s):  
Gold Catalysis ◽  
Reaction Pathways ◽  
High Yield ◽  
Reaction Conditions ◽  
Propargylic Alcohols ◽  
Catalytic Quantity ◽  
Selective Formation ◽  
General Method

A versatile approach to the valorization of propargylic alcohols is reported, enabling controlled access to three different products from the same starting materials. Firstly, a general method for the hydroamination of propargylic alcohols with anilines is described using gold catalysis to give 3-hydroxy imines with complete regioselectivity. These 3-hydroxyimines can be reduced to give 1,3-aminoalcohols with high syn seletivity. Alternatively, by using a catalytic quantity of aniline, 3-hydroxyketones can be obtained in high yield directly from propargylic alcohols. Further manipulation of the reaction conditions enables the selective formation of 3-aminoketones via a rearrangement/hydroamination pathway.<br>

scholarly journals Water Can Accelerate Homogeneous Gold Catalysis

2021 ◽  
Author(s):  
Philipp Stein ◽  
Matthias Rudolph ◽  
A. Stephen K. Hashmi
Keyword(s):  
Gold Catalysis

scholarly journals A gold-catalyzed alkyne-diol cycloisomerization for the synthesis of oxygenated 5,5-spiroketals

2011 ◽  
Vol 7 ◽  
pp. 570-577 ◽  
Author(s):  
Sami F Tlais ◽  
Gregory B Dudley
Keyword(s):  
Transition Metal ◽  
Lewis Acids ◽  
Gold Catalysis ◽  
Late Transition Metal ◽  
Efficient Synthesis ◽  
Highly Efficient ◽  
Late Transition

A highly efficient synthesis of oxygenated 5,5-spiroketals was performed towards the synthesis of the cephalosporolides. Gold(I) chloride in methanol induced the cycloisomerization of a protected alkyne triol with concomitant deprotection to give a strategically hydroxylated 5,5-spiroketal, despite the potential for regiochemical complications and elimination to furan. Other late transition metal Lewis acids were less effective. The use of methanol as solvent helped suppress the formation of the undesired furan by-product. This study provides yet another example of the advantages of gold catalysis in the activation of alkyne π-systems.

Molecular diversity through gold catalysis with alkynes

2007 ◽  
pp. 333-346 ◽  
Author(s):  
Eloísa Jiménez-Núñez ◽  
Antonio M. Echavarren
Keyword(s):  
Molecular Diversity ◽  
Gold Catalysis

Divergent Gold Catalysis: Unlocking Molecular Diversity through Catalyst Control

2021 ◽  
Author(s):  
Chetan C. Chintawar ◽  
Amit K. Yadav ◽  
Anil Kumar ◽  
Shashank P. Sancheti ◽  
Nitin T. Patil
Keyword(s):  
Molecular Diversity ◽  
Gold Catalysis

ChemInform Abstract: π-Extended DPCB for Activation-Free Homogeneous Gold Catalysis.

ChemInform ◽  
2015 ◽  
Vol 46 (5) ◽  
pp. no-no
Author(s):  
Shigekazu Ito ◽  
Masaki Nanko ◽  
Koichi Mikami
Keyword(s):  
Gold Catalysis

New Endeavors in Gold Catalysis-Size Matters

2013 ◽  
Vol 52 (50) ◽  
pp. 13146-13148 ◽  
Author(s):  
Rafael Gramage-Doria ◽  
Joost N. H. Reek
Keyword(s):  
Gold Catalysis

Cycloaddition versus Alkylation Reactions of 2-Vinylindoles with α,β-Unsaturated Carbonyl Compounds Under Gold Catalysis

2013 ◽  
Vol 2013 (28) ◽  
pp. 6267-6279 ◽  
Author(s):  
Valentina Pirovano ◽  
Monica Dell'Acqua ◽  
Diego Facoetti ◽  
Donatella Nava ◽  
Silvia Rizzato ◽  
...  
Keyword(s):  
Carbonyl Compounds ◽  
Gold Catalysis ◽  
Alkylation Reactions

Homogeneous Gold Catalysis: Hydration of 1,2-Diphenylacetylene with Methanol in Aqueous Media. A Theoretical Viewpoint

2012 ◽  
Vol 31 (8) ◽  
pp. 3074-3080 ◽  
Author(s):  
Gloria Mazzone ◽  
Nino Russo ◽  
Emilia Sicilia
Keyword(s):  
Aqueous Media ◽  
Gold Catalysis
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